PMC:4996401 / 29547-30676 JSONTXT

{"project":"2_test","denotations":[{"id":"27600240-1359641-69474566","span":{"begin":436,"end":438},"obj":"1359641"},{"id":"27600240-15561999-69474567","span":{"begin":442,"end":444},"obj":"15561999"},{"id":"27600240-23941516-69474568","span":{"begin":445,"end":447},"obj":"23941516"},{"id":"27600240-23288647-69474569","span":{"begin":448,"end":450},"obj":"23288647"},{"id":"27600240-22289488-69474570","span":{"begin":451,"end":453},"obj":"22289488"},{"id":"27600240-18645599-69474571","span":{"begin":856,"end":858},"obj":"18645599"},{"id":"27600240-22413963-69474572","span":{"begin":859,"end":861},"obj":"22413963"},{"id":"27600240-22413963-69474573","span":{"begin":1119,"end":1121},"obj":"22413963"},{"id":"27600240-23227038-69474574","span":{"begin":1122,"end":1124},"obj":"23227038"},{"id":"27600240-21587300-69474575","span":{"begin":1125,"end":1127},"obj":"21587300"}],"text":"4. Conclusions\nWith the advent of SNP arrays, a large number of genetic abnormalities have been described. This is mainly a result of its improved resolution compared to the more traditional methods like CGH and FISH. The newly discovered genetic alterations, such as CNVs and LOHs, have improved our understanding of the pathology of different human tumors, as well as provided us with new markers for diagnosis and therapy selection [11,12,13,14,15,16]. However, as any other technique, it has its own limitations; particularly, the lack of possibility for detecting inversions and balanced chromosomal translocations and the need, if optimal results are aimed, for normal matched DNA, has largely limited an extensive clinical application so far. However, a combination of SNP array along with other techniques such as FISH has often been accommodated [87,88]. Currently, NGS-based approaches are overcoming the limits of SNP arrays and cytogenetic technologies. SNP arrays, however, probably will continue to be used in diagnosis, as they offer more economic possibilities when compared to the current NGS options [88,89,90]."}