PMC:4996398 / 46029-46815 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4996398","sourcedb":"PMC","sourceid":"4996398","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4996398","text":"4.1.1. Cancer\nAlready in 1990 an alginate culture method was used to test the effects of vincristine and 5‑fluorouracil on HT-29 human colon carcinoma cells [130]. Creating a more clinically relevant model of tumor biology has been a prime impetus for developing 3D culture systems. Burdett et al. [131] described the superiority of 3D over 2D cell culture where mimicking tumor behavior and drug resistance often seen in vivo is important. AlgiMatrix® is a commercial alginate-based product for 3D cell culture. Godugu et al. [110] demonstrate the possibility of using this culture system as an in vitro tumor model for anticancer drug screening. They treated several human non-small cell lung cancer cell lines (A549, H460, and H1650) with several anticancer drugs used in the clinic.","divisions":[{"label":"Title","span":{"begin":0,"end":13}}],"tracks":[{"project":"2_test","denotations":[{"id":"27600217-2337892-69475977","span":{"begin":158,"end":161},"obj":"2337892"},{"id":"27600217-23349734-69475978","span":{"begin":528,"end":531},"obj":"23349734"}],"attributes":[{"subj":"27600217-2337892-69475977","pred":"source","obj":"2_test"},{"subj":"27600217-23349734-69475978","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecc9","default":true}]}]}}