PMC:4928686 / 8566-9397 JSONTXT

{"project":"2_test","denotations":[{"id":"25788396-21573031-121220481","span":{"begin":409,"end":410},"obj":"21573031"},{"id":"25788396-21573031-121220481","span":{"begin":409,"end":410},"obj":"21573031"},{"id":"25788396-17507983-121220482","span":{"begin":412,"end":414},"obj":"17507983"},{"id":"25788396-17507983-121220482","span":{"begin":412,"end":414},"obj":"17507983"},{"id":"25788396-16521279-121220483","span":{"begin":415,"end":418},"obj":"16521279"},{"id":"25788396-16521279-121220483","span":{"begin":415,"end":418},"obj":"16521279"},{"id":"25788396-21379581-121220484","span":{"begin":610,"end":612},"obj":"21379581"},{"id":"25788396-21379581-121220484","span":{"begin":610,"end":612},"obj":"21379581"},{"id":"25788396-19176439-121220484","span":{"begin":610,"end":612},"obj":"19176439"},{"id":"25788396-19176439-121220484","span":{"begin":610,"end":612},"obj":"19176439"},{"id":"25788396-20400465-121220484","span":{"begin":610,"end":612},"obj":"20400465"},{"id":"25788396-20400465-121220484","span":{"begin":610,"end":612},"obj":"20400465"},{"id":"25788396-16147978-121220485","span":{"begin":617,"end":619},"obj":"16147978"},{"id":"25788396-16147978-121220485","span":{"begin":617,"end":619},"obj":"16147978"},{"id":"25788396-16521279-68933162","span":{"begin":408,"end":410},"obj":"16521279"},{"id":"25788396-16521279-68933162","span":{"begin":408,"end":410},"obj":"16521279"},{"id":"25788396-17507983-68933163","span":{"begin":412,"end":414},"obj":"17507983"},{"id":"25788396-17507983-68933163","span":{"begin":412,"end":414},"obj":"17507983"},{"id":"25788396-21573031-68933164","span":{"begin":416,"end":418},"obj":"21573031"},{"id":"25788396-21573031-68933164","span":{"begin":416,"end":418},"obj":"21573031"},{"id":"25788396-21379581-68933165","span":{"begin":610,"end":612},"obj":"21379581"},{"id":"25788396-21379581-68933165","span":{"begin":610,"end":612},"obj":"21379581"},{"id":"25788396-19176439-68933165","span":{"begin":610,"end":612},"obj":"19176439"},{"id":"25788396-19176439-68933165","span":{"begin":610,"end":612},"obj":"19176439"},{"id":"25788396-20400465-68933165","span":{"begin":610,"end":612},"obj":"20400465"},{"id":"25788396-20400465-68933165","span":{"begin":610,"end":612},"obj":"20400465"},{"id":"25788396-16147978-68933166","span":{"begin":617,"end":619},"obj":"16147978"},{"id":"25788396-16147978-68933166","span":{"begin":617,"end":619},"obj":"16147978"}],"text":"On the other hand, the septic response is considered by many to be a deranged host response, and it is equally logical that CMV preconditioning might contribute to such exaggerated inflammation. Hosts with coincident CMV reactivation and bacterial infections have more inflammation and immune system activation that is accompanied by an increased risk of septic shock, supporting the detrimental hypothesis [34, 35, 44]. By looking at the CMV-specific immune responses to infection in human hosts, it seems clear that not all naturally occurring infections are equal and show a broad mix of infectious titers [41–43, 45]. This mix of high- and low-titer infections may in part explain why the work by De Vlieger et al. did not show an advantage or disadvantage of previous CMV infection in outcome after sepsis or critical illness."}