PMC:4928686 / 6071-7618
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4928686","sourcedb":"PMC","sourceid":"4928686","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4928686","text":"Interestingly, this enhanced TLR responsiveness might actually provide a survival advantage for the virus, by ensuring that the major immediate early promoter is tickled repeatedly (if not continuously) by endogenous bacteria throughout an infected host’s lifetime, perhaps causing shedding of virus and thus transmission opportunities. If this hypothesis is true, then one would expect to see some differences in germ-free hosts after CMV infection. It is known that CMV infection can induce dramatic CMV-specific T cell responses, a phenomenon that is popularly referred to as “memory inflation.” Curiously germ-free mice do not develop memory inflation after CMV infection, but do develop memory inflation after bacterial reconstitution [37]. If CMV-specific T cells are inflating in response to viral transcriptional activity, then one could speculate that host bacteria facilitate such activity. This makes the enhanced TLR/CD14 expression after CMV infection even more interesting, leaving hosts even more susceptible to bacterial stimulation and inflammation. Such stimulation might explain the perpetual low-level viral transcriptional activity during “latency” shown by the Reddehase group [38, 39], and in moments of immune weakness during relative health allow intermittent shedding, giving survival advantage to the virus. Conversely, such enhancements in Toll-like receptors might also contribute to the exaggerated immune responses seen during sepsis, becoming detrimental when those same hosts encounter severe bacterial infections.","tracks":[{"project":"2_test","denotations":[{"id":"25788396-17404304-121220476","span":{"begin":741,"end":743},"obj":"17404304"},{"id":"25788396-17404304-121220476","span":{"begin":741,"end":743},"obj":"17404304"},{"id":"25788396-10482614-121220477","span":{"begin":1204,"end":1206},"obj":"10482614"},{"id":"25788396-10482614-121220477","span":{"begin":1204,"end":1206},"obj":"10482614"},{"id":"25788396-17404304-68933156","span":{"begin":741,"end":743},"obj":"17404304"},{"id":"25788396-17404304-68933156","span":{"begin":741,"end":743},"obj":"17404304"},{"id":"25788396-22991040-68933157","span":{"begin":1200,"end":1202},"obj":"22991040"},{"id":"25788396-22991040-68933157","span":{"begin":1200,"end":1202},"obj":"22991040"},{"id":"25788396-10482614-68933158","span":{"begin":1204,"end":1206},"obj":"10482614"},{"id":"25788396-10482614-68933158","span":{"begin":1204,"end":1206},"obj":"10482614"}],"attributes":[{"subj":"25788396-17404304-121220476","pred":"source","obj":"2_test"},{"subj":"25788396-17404304-121220476","pred":"source","obj":"2_test"},{"subj":"25788396-10482614-121220477","pred":"source","obj":"2_test"},{"subj":"25788396-10482614-121220477","pred":"source","obj":"2_test"},{"subj":"25788396-17404304-68933156","pred":"source","obj":"2_test"},{"subj":"25788396-17404304-68933156","pred":"source","obj":"2_test"},{"subj":"25788396-22991040-68933157","pred":"source","obj":"2_test"},{"subj":"25788396-22991040-68933157","pred":"source","obj":"2_test"},{"subj":"25788396-10482614-68933158","pred":"source","obj":"2_test"},{"subj":"25788396-10482614-68933158","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#e3ec93","default":true}]}]}}