PMC:4928686 / 16236-17204 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4928686","sourcedb":"PMC","sourceid":"4928686","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4928686","text":"Conclusions\nThere is a strong and long-standing association between CMV reactivation and sepsis. It is currently unclear whether CMV and sepsis are friend or foe. On the one hand, there is evidence that previous CMV infection can protect against subsequent bacterial infection by enhanced macrophage activation. On the other hand, this same immune enhancement may contribute to exaggerated inflammatory responses during sepsis leading to septic shock and patient mortality. Determining how preconditioned immune responses to persistent herpesviruses impact subsequent immune system activation and inflammatory responses may provide significant insight into septic responses. Given the enormous number of patients that harbor latent CMV that become critically ill, and the attendant mortality associated with CMV reactivation, developing better understanding of CMV reactivation and possible new strategies to prevent it may significantly contribute to patient outcome.","divisions":[{"label":"title","span":{"begin":0,"end":11}}],"tracks":[]}