PMC:4928686 / 11895-13136 JSONTXT

{"project":"2_test","denotations":[{"id":"25788396-19424209-121220492","span":{"begin":287,"end":289},"obj":"19424209"},{"id":"25788396-19424209-121220492","span":{"begin":287,"end":289},"obj":"19424209"},{"id":"25788396-10482614-121220494","span":{"begin":529,"end":531},"obj":"10482614"},{"id":"25788396-10482614-121220494","span":{"begin":529,"end":531},"obj":"10482614"},{"id":"25788396-22730545-121220495","span":{"begin":674,"end":676},"obj":"22730545"},{"id":"25788396-22730545-121220495","span":{"begin":674,"end":676},"obj":"22730545"},{"id":"25788396-18397464-121220496","span":{"begin":763,"end":765},"obj":"18397464"},{"id":"25788396-18397464-121220496","span":{"begin":763,"end":765},"obj":"18397464"},{"id":"25788396-20572085-121220497","span":{"begin":906,"end":907},"obj":"20572085"},{"id":"25788396-20572085-121220497","span":{"begin":906,"end":907},"obj":"20572085"},{"id":"25788396-24919177-121220498","span":{"begin":1237,"end":1239},"obj":"24919177"},{"id":"25788396-24919177-121220498","span":{"begin":1237,"end":1239},"obj":"24919177"},{"id":"25788396-24919177-68933174","span":{"begin":283,"end":285},"obj":"24919177"},{"id":"25788396-24919177-68933174","span":{"begin":283,"end":285},"obj":"24919177"},{"id":"25788396-19424209-68933175","span":{"begin":287,"end":289},"obj":"19424209"},{"id":"25788396-19424209-68933175","span":{"begin":287,"end":289},"obj":"19424209"},{"id":"25788396-22991040-68933176","span":{"begin":529,"end":531},"obj":"22991040"},{"id":"25788396-22991040-68933176","span":{"begin":529,"end":531},"obj":"22991040"},{"id":"25788396-10482614-68933177","span":{"begin":533,"end":535},"obj":"10482614"},{"id":"25788396-10482614-68933177","span":{"begin":533,"end":535},"obj":"10482614"},{"id":"25788396-22730545-68933178","span":{"begin":674,"end":676},"obj":"22730545"},{"id":"25788396-22730545-68933178","span":{"begin":674,"end":676},"obj":"22730545"},{"id":"25788396-18397464-68933179","span":{"begin":763,"end":765},"obj":"18397464"},{"id":"25788396-18397464-68933179","span":{"begin":763,"end":765},"obj":"18397464"},{"id":"25788396-20572085-68933180","span":{"begin":906,"end":907},"obj":"20572085"},{"id":"25788396-20572085-68933180","span":{"begin":906,"end":907},"obj":"20572085"},{"id":"25788396-24919177-68933181","span":{"begin":1237,"end":1239},"obj":"24919177"},{"id":"25788396-24919177-68933181","span":{"begin":1237,"end":1239},"obj":"24919177"}],"text":"The association between CMV reactivation and mortality naturally prompts the question of pathogen or bystander. Several authors have suggested that CMV reactivation events are merely an indicator of host immune compromise, which has been associated by itself with worsened outcomes [15, 51]. Because most investigators agree that CMV is never fully quiescent, requiring constant immune surveillance to maintain functional latency, it makes sense that transient immune compromise during critical illness could allow reactivation [38, 39]. It is now clear that sepsis can induce contraction of CMV-specific T memory in mice, thereby facilitating transcriptional reactivation [52]. Likewise, sepsis has been shown to cause contraction of CMV-specific IgG in humans [26]. Limited data on CMV-specific T immunity in non-immune-suppressed humans during critical illness show persistence of CMV-specific T cells [8]. Given the lack of pre-illness baseline data, however, it is impossible to know whether the presence of such T cells is indicative of “intact” CMV-specific immune function or some fraction thereof. Also consistent with the immune compromise hypothesis is the observation that other human herpesviruses reactivate during sepsis [15]."}