PMC:4925684 / 2350-3587 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4925684","sourcedb":"PMC","sourceid":"4925684","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4925684","text":"By 2013 his CD4+ T cell count had been over 500 cells/μl for 7 years, and HIV RNA had been undetectable for a decade. Annual MRI brain scans since 2008 (Figs. 1, 2 and 3) showed progressive white matter atrophy, and since 2010 asymptomatic fluctuating contrast enhancement without mass effect, in both cortical grey and subcortical white matter.\nFig. 1 Case one, 2008: Fluid attenuated inversion recovery (FLAIR) MRI sequences showing multifocal hyperintensity in the subcortical U-fibres of the right basifrontal, right temporal, and left parieto-occipital regions (see arrows). The corresponding T1 post contrast images (lower row), demonstrate an absence of enhancement\nFig. 2 Case one, 2011: FLAIR MRI sequences from 2011 again show hyperintensity in the right basifrontal (see arrows) and left parieto-occipital regions, now with enhancement on corresponding post contrast T1 images (lower row) in the right basifrontal region only\nFig. 3 Case one, 2013: FLAIR hyperintensity has increased in the left parieto-occipital region (see arrows, top images), with new gyriform enhancement (see arrows, bottom images) on corresponding pre-contrast FLAIR sequences. The right basifrontal contrast enhancement has shown a complete resolution","divisions":[{"label":"figure","span":{"begin":346,"end":672}},{"label":"label","span":{"begin":346,"end":352}},{"label":"caption","span":{"begin":353,"end":672}},{"label":"p","span":{"begin":353,"end":672}},{"label":"figure","span":{"begin":673,"end":936}},{"label":"label","span":{"begin":673,"end":679}},{"label":"caption","span":{"begin":680,"end":936}},{"label":"p","span":{"begin":680,"end":936}},{"label":"label","span":{"begin":937,"end":943}}],"tracks":[]}