PMC:4925684 / 1366-2010 JSONTXT

{"project":"2_test","denotations":[{"id":"26727910-2876640-63343915","span":{"begin":638,"end":642},"obj":"2876640"},{"id":"26727910-2876640-63343915","span":{"begin":638,"end":642},"obj":"2876640"},{"id":"T2090","span":{"begin":638,"end":642},"obj":"2876640"},{"id":"T27884","span":{"begin":638,"end":642},"obj":"2876640"}],"text":"In the early 2000s his CD4+ T cell count was at a lifetime nadir of 70 cells/μl, plasma HIV RNA 5 · 35 log, and cerebrospinal fluid (CSF) 4 · 69 log. At that time he had cognitive impairment consistent with HIV associated neurocognitive disorder (HAND) with an MRI brain showing multifocal grey and white matter hyperintensities. CSF was normal including negative PCR for JC virus (JCV) DNA, but a right frontal lobe biopsy showed oligodendrocyte nuclei with viral inclusions, prominent reactive astrocytes including bizarre forms, and was strongly positive for JCV DNA by PCR. HIV associated encephalitis was also present (Anders et al. 1986)."}