PMC:4913875 / 3550-4472 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4913875","sourcedb":"PMC","sourceid":"4913875","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4913875","text":"Despite technological progress, the durability of conventional biological prostheses in young patients remains debatable. Rapid degeneration and subsequent failure of biological allo- and xenografts is generally attributed to the patient's immunological response to remaining cellular components within the graft tissue. The lower durability of these types of grafts in patients with higher immunological competence, such as children and young adults, supports this assumption [7, 8]. Decellularization of valved allografts has demonstrated a reduced immunological response to the resulting valve scaffold [9–11]. Several clinical studies have revealed higher freedom from graft explantation, lower transvalvular gradients for decellularized pulmonary homografts (DPHs) in comparison with conventional cryopreserved homografts and xenografts, when used for pulmonary valve replacement in children and young adults [12–14].","tracks":[{"project":"TEST0","denotations":[{"id":"26896320-157-162-6132","span":{"begin":478,"end":479},"obj":"[\"16515905\"]"},{"id":"26896320-160-165-6133","span":{"begin":481,"end":482},"obj":"[\"20684981\"]"},{"id":"26896320-122-127-6134","span":{"begin":607,"end":608},"obj":"[\"19703713\", \"24138470\", \"25907532\"]"},{"id":"26896320-236-242-6135","span":{"begin":915,"end":917},"obj":"[\"22340029\", 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