PMC:4913875 / 32103-32837 JSONTXT

{"project":"testtesttest","denotations":[{"id":"T189","span":{"begin":57,"end":64},"obj":"Body_part"}],"attributes":[{"id":"A189","pred":"uberon_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/UBERON_0000161"}],"text":"The lack of need for anticoagulation therapy, the larger orifice area as well as the expected reduced immunogenicity of DAHs might positively influence a decision for this graft, especially in women of reproductive age. In our cohort of patients with decellularized homografts, 2 patients, 1 with a DPH and 1 with a DAH, have given birth to healthy newborns. Both women remained asymptomatic from a cardiac perspective throughout the pregnancy and did not reveal any decline in graft function after delivery. To the best of our knowledge, this is the first report of successful pregnancy in patients with decellularized homografts. Our data suggest that a DAH may be considered as an option for AVR in women wishing to start a family."}