PMC:4913875 / 30985-32102 JSONTXT

{"project":"testtesttest","denotations":[{"id":"T179","span":{"begin":24,"end":29},"obj":"Body_part"},{"id":"T180","span":{"begin":59,"end":66},"obj":"Body_part"},{"id":"T181","span":{"begin":94,"end":106},"obj":"Body_part"},{"id":"T182","span":{"begin":176,"end":188},"obj":"Body_part"},{"id":"T183","span":{"begin":324,"end":338},"obj":"Body_part"},{"id":"T184","span":{"begin":859,"end":864},"obj":"Body_part"},{"id":"T188","span":{"begin":1037,"end":1042},"obj":"Body_part"}],"attributes":[{"id":"A179","pred":"uberon_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/UBERON_0003978"},{"id":"A180","pred":"uberon_id","subj":"T180","obj":"http://purl.obolibrary.org/obo/UBERON_0000161"},{"id":"A181","pred":"uberon_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/UBERON_0002137"},{"id":"A182","pred":"uberon_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/UBERON_0002137"},{"id":"A183","pred":"uberon_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/UBERON_0002084"},{"id":"A184","pred":"uberon_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A185","pred":"uberon_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"A186","pred":"uberon_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"A187","pred":"uberon_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/UBERON_0015230"},{"id":"A188","pred":"uberon_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/UBERON_0003978"}],"text":"In fact, most available valve prostheses exhibit a smaller orifice area than that of a normal aortic valve (in adults, \u003e2.5 cm2). A mismatch between the anatomical ring of the aortic valve and the implanted graft has an important impact on perioperative short- or long-term survival and the postoperative remodelling of the left ventricle [24]. Patient-prosthesis mismatch (PPM), defined in three grades, is calculated by dividing the EOA by the BSA to obtain the EOA index. PPM is defined as none by an EOA index \u003e0.85 cm2/m2, as moderate at 0.65–0.85 cm2/m2 and as severe at \u003c0.65 cm2/m2. Moderate and severe PPM increases operative mortality by 2.1- and 11.4-fold, respectively [25]. Several studies indicate that moderate PPM is found in up to 30% of patients after AVR and, in some cases, complex reoperations are required in order to prevent congestive heart failure. In our study, the mean diameter of implanted DAHs of 25 mm size was 3.07 ± 0.7 cm2. In comparison, the average EOAs of a 25-mm Carpentier-Edwards Magna biological valve and 25-mm SJM Regent mechanical valves are 2.01 and 2.6 cm2, respectively."}