PMC:4913875 / 29403-30607 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4913875","sourcedb":"PMC","sourceid":"4913875","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4913875","text":"At present, only experimental data in the growing sheep model have been available to evaluate potential for growth in decellularized aortic allografts. In our study, we present for the first time clinical data of DAH implantation in 16 patients younger than 10 years. Although our mean follow-up is very short in this group of patients, limiting meaningful discussion on the subject of graft degeneration, the issue of adaptive growth of the decellularized grafts can be cautiously addressed. In our youngest patient with a DAH of 10 mm that required LVOT enlargement 4.5 years postoperatively, the subvalvular problem appeared intraoperatively as a combination of LVOT obstruction, commonly associated with congenital aortic stenosis, and proximal DAH anastomosis. Despite the subvalvular stenosis and development of clinically relevant regurgitation, severe LV hypertrophy and impaired LV function recovered postoperatively to normal values and allowed the physiological development of the child over a 4.5-year postoperative period. Implantation of a 17-mm DAH including coronary reimplantation was performed in a routine operation as no calcification was observed macroscopically and microscopically.","tracks":[{"project":"testtesttest","denotations":[{"id":"T176","span":{"begin":551,"end":555},"obj":"Body_part"},{"id":"T177","span":{"begin":665,"end":669},"obj":"Body_part"}],"attributes":[{"id":"A176","pred":"uberon_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/UBERON_0005956"},{"id":"A177","pred":"uberon_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/UBERON_0005956"},{"subj":"T176","pred":"source","obj":"testtesttest"},{"subj":"T177","pred":"source","obj":"testtesttest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"testtesttest","color":"#93a7ec","default":true}]}]}}