PMC:4913875 / 17698-19354 JSONTXT

{"project":"testtesttest","denotations":[{"id":"T112","span":{"begin":244,"end":258},"obj":"Body_part"},{"id":"T113","span":{"begin":288,"end":302},"obj":"Body_part"},{"id":"T114","span":{"begin":370,"end":382},"obj":"Body_part"},{"id":"T115","span":{"begin":428,"end":435},"obj":"Body_part"},{"id":"T116","span":{"begin":1036,"end":1048},"obj":"Body_part"}],"attributes":[{"id":"A112","pred":"uberon_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/UBERON_0002084"},{"id":"A113","pred":"uberon_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/UBERON_0002084"},{"id":"A114","pred":"uberon_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/UBERON_0002416"},{"id":"A115","pred":"uberon_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/UBERON_0000161"},{"id":"A116","pred":"uberon_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/UBERON_0002137"}],"text":"Haemodynamic performance of DAH\nThe mean diameter of implanted DAHs was 22.4 ± 3.7 mm (range, 10–29 mm), the average peak gradient was 14 ± 15 mmHg and the mean aortic regurgitation grade (0.5 = trace and 1 = mild) was 0.6 ± 0.5. The last mean left ventricle ejection fraction (LVEF) and left ventricle end diastolic volume index (LV EDVi) was 63 ± 7% and 78 ± 16 ml/m2 body surface area (BSA), respectively. The mean effective orifice area (EOA) of a 25-mm diameter DAH was 3.07 ± 0.7 cm2.\nFigures 1 and 2 show the development of mean gradients and regurgitation in the DAH over time.\nFigure 1: Echocardiographic mean gradient over time in the DAH. Different colours represent different patients; loess-smoothed lines are interpolated between the measurements for each individual. Some individuals show gradients that decrease over time.\nFigure 2: Valvular regurgitation over time in DAH (0 = none, 0.5 = trace, 1 = mild, 1.5 = mild to moderate, 2 = moderate, 2.5 = moderate to severe and 3 = severe). This figure shows the individual aortic valve insufficiency development and loess-smoothed interpolation lines. The decrease of insufficiency is not uncommon.\nFigure 3 summarizes the portion of explanted, well-functioning and dysfunctional grafts (\u003e49 mm Hg peak gradient and/or at least moderate regurgitation) at the various examination intervals. For 3 Moldavian patients, only clinical follow-up was available.\nFigure 3: Freedom from explantation including the percentage of conduits with degeneration signs for the DAH (peak gradient \u003e49 mmHg and/or at least moderate regurgitation). For 3 Moldavian patients, only clinical follow-up was available."}