PMC:4913875 / 11017-13424 JSONTXT

{"project":"testtesttest","denotations":[{"id":"T70","span":{"begin":903,"end":907},"obj":"Body_part"},{"id":"T71","span":{"begin":1070,"end":1082},"obj":"Body_part"},{"id":"T72","span":{"begin":1143,"end":1155},"obj":"Body_part"},{"id":"T73","span":{"begin":1210,"end":1225},"obj":"Body_part"},{"id":"T74","span":{"begin":2126,"end":2138},"obj":"Body_part"},{"id":"T75","span":{"begin":2195,"end":2207},"obj":"Body_part"},{"id":"T76","span":{"begin":2322,"end":2336},"obj":"Body_part"},{"id":"T77","span":{"begin":2365,"end":2379},"obj":"Body_part"}],"attributes":[{"id":"A70","pred":"uberon_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"A71","pred":"uberon_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/UBERON_0002137"},{"id":"A72","pred":"uberon_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/UBERON_0002135"},{"id":"A73","pred":"uberon_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/UBERON_0002146"},{"id":"A74","pred":"uberon_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/UBERON_0002137"},{"id":"A75","pred":"uberon_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/UBERON_0002137"},{"id":"A76","pred":"uberon_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/UBERON_0002084"},{"id":"A77","pred":"uberon_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/UBERON_0002084"}],"text":"A total of 69 patients underwent AVR using a DAH in the period between February 2008 and September 2015. The mean time from allograft harvesting until implantation was 41 ± 11 days. Postoperative follow-up was complete, except for 3 Moldavian patients, where only clinical follow-up was available. However, CMR imaging has been initiated for these patients. The observation time was 140.4 years in total, mean 2.0 ± 1.8 years, maximum 7.6 years. The demographic data of the patients stratified by age subgroups are presented in Table 1.\nTable 1: Patient cohort description according to age groups\nPatient age groupDAH diameter All \u003c10 years \u003c10 years \u003e10 years\n\u003c15 mm ≥15 mm ≥19 mm\nNumber of patients 69 4 12 53\nMean age at implantation (years) 19.7 ± 14.6 1.4 ± 1.2 6.4 ± 2.1 24.1 ± 13.8\nMean follow-up (years) 2.0 ± 1.8 3.3 ± 1.1 1.9 ± 2.2 2.0 ± 1.7\nTotal follow-up (years) 140.4 13.0 22.6 104.8\nSex, male (%) 64 50 75 62\nCongenital AS/AI/AS + AI 24/2/5 3/0/0 6/1/0 15/1/5\nAcquired AS/AI/AS + AI 10/5/13 0/0/0 0/0/0 10/5/3\nPrevious procedures\n Commissurotomy 7 2 1 4\n Aortic valve reconstruction 12 0 4 8\n Ascending aortic aneurysm 1 0 0 3\n Mitral valve disease 3 1 0 2\n Subvalvular aortic stenosis 7 0 3 4\n Pulmonary valve disease 3 0 0 3\n Ross 2 0 0 2\nNo. of previous cardiac surgeries/with ECC/with AVR\n 1 25/25/12 3/3/0 4/4/2 18/17/10\n 2 5/5/4 0/0/0 1/1/0 4/4/4\n 3 and more 9/7/0 0/0/0 2/2/0 7/5/0\nPrevious catheter interventions\n Balloon dilatation 18 2 5 11\nDAH diameter (mm)\n 10–18 7 4 3 0\n 19–22 22 0 8 14\n 23–29 40 0 1 39\nOperation time (min)\n Mean OP time 359.2 ± 101.3 417.3 ± 108.6 387.6 ± 72.8 348.5 ± 104.9\n Extracorporeal circulation 220.8 ± 74.6 266.3 ± 103.1 234.7 ± 58.7 214.0 ± 75.3\n Aortic cross-clamp time 139.0 ± 45.5 138.3 ± 52.5 147.9 ± 40.9 137.1 ± 46.6\nAt last follow-up\n Mean DAH diameter (mm) 21.8 ± 4.4 12.5 ± 1.7 17.3 ± 3.2 23.4 ± 3.2\n Mean peak gradient (mmHg) 13.9 ± 15.3 58.0 ± 33.4 9.5 ± 6.8 11.5 ± 8.4\n Mean regurgitation, grade 0.6 ± 0.5 1.4 ± 1.1 0.7 ± 0.4 0.5 ± 0.4\n Mean LVEF (%) 62.8 ± 7.2 65.1 ± 6.5 68.0 ± 0.0 62.3 ± 7.5\n Mean LV EDVi (ml/m2) 77.8 ± 15.7 69.0 ± 18.4 − 78.8 ± 15.5\n Aortic valve z-values 0.7 ± 1.3 −0.4 ± 0.7 0.3 ± 1.3 0.63 ± 1.2\nAVR: aortic valve replacement; AS: aortic stenosis; AI: aortic insufficiency; ECC: extracorporeal circulation; OP: operation; LVEF: left ventricle ejection fraction; LV EDVi: left ventricle end diastolic volume index."}