PMC:4845325 / 48120-48919 JSONTXT

{"project":"2_test","denotations":[{"id":"27112350-16077740-72613536","span":{"begin":283,"end":285},"obj":"16077740"},{"id":"27112350-20598278-72613537","span":{"begin":349,"end":351},"obj":"20598278"}],"text":"We corrected for testing multiple SNPs in a gene after accounting for correlation between SNP genotypes due to linkage disequilibrium. Each gene tested was treated as an independent hypothesis and the effective number of tests per gene was obtained by a previously described method [83]. The Versatile Gene-based Association Study (VEGAS) approach [84] was used to summarize the strength of association of a gene with AD based on the number of SNPs tested in the gene and size of the gene. This method computes a gene-based test statistic based on the SNP p-values within the gene, and then uses simulation to calculate an empirical gene-based p-value. The distribution of empirical p-values was then plotted and tested against an expected distribution of p-values using the Kolmogorov-Smirnov test."}