PMC:4845325 / 3743-5160 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4845325","sourcedb":"PMC","sourceid":"4845325","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4845325","text":"The circulatory AD signaling proteome reveals changes in cellular communication. a Overview of the experimental and analysis workflow. Plasma samples were collected at clinical centers, relative protein abundance was determined by antibody microarray and three types of analyses were performed: Protein level, MMSE correlation (cognitive performance), and protein co-secretion analysis. The analyses results were then integrated in a network and pathway enrichment framework and finally subjected to internal and external validation. b Heat map representation of the protein level analysis showing the top 50 most different proteins after unsupervised clustering (q \u003c 0.05), separating samples into AD (pink, right) and controls (blue, left) and proteins into higher in control (blue, top) and higher in AD (pink, bottom). c Volcano-plot showing the distribution of all proteins and naming those significantly different between AD and control subjects (p corr \u003c 0.01). d A network representation of the most significantly changed proteins (p corr \u003c 0.015; un-connected proteins omitted) after integration with known pathway and physical interaction data reveals many densely connected hits in pathways related to TGFβ/GDF/BMP, angiogenesis, and apoptosis signaling. e Example scatter plots of the six top changed proteins (see dashed box in e, mean ± s.e.m; all p-values are corrected for multiple hypothesis testing)","tracks":[]}