PMC:4845325 / 20209-21290 JSONTXT

{"project":"2_test","denotations":[{"id":"27112350-22216330-72613490","span":{"begin":989,"end":991},"obj":"22216330"}],"text":"The results thus far from the differential protein level analysis, the correlations with cognitive function, and the co-expression network analysis consistently implicate the complement pathway, apoptosis, and a signaling network around the TGFβ superfamily in AD. We were particularly intrigued by this latter network, and its GDF family members, many of which had not been linked to AD. To further validate the significance of this finding we asked whether any of the proteins in this pathway – including intra- or extracellular ones not measured with the array – were additionally linked to AD at the genomic or transcript level. We used the Gene Ontology to identify a list of 114 genes linked to the TGFβ/GDF/BMP signaling pathway (Additional file 2) and queried two large AD data sets consisting of meta-data from 10 genome-wide association studies with a total of 8,309 AD cases and 7,366 cognitively normal elders [23] and AD brain transcriptome data from 181 AD and 125 controls [24] for significant SNPs or mRNA changes within the TGFβ/GDF/BMP pathway associated with AD."}