| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T42 |
0-10 |
sentence |
denotes |
Background |
| T43 |
0-10 |
NN |
denotes |
Background |
| T44 |
10-112 |
sentence |
denotes |
Little is known about genetic factors affecting intraocular pressure (IOP) in mice and other mammals. |
| T45 |
11-17 |
JJ |
denotes |
Little |
| T46 |
21-26 |
VBN |
denotes |
known |
| T47 |
18-20 |
VBZ |
denotes |
is |
| T48 |
27-32 |
IN |
denotes |
about |
| T49 |
33-40 |
JJ |
denotes |
genetic |
| T50 |
41-48 |
NNS |
denotes |
factors |
| T51 |
49-58 |
VBG |
denotes |
affecting |
| T52 |
59-70 |
JJ |
denotes |
intraocular |
| T53 |
71-79 |
NN |
denotes |
pressure |
| T54 |
80-81 |
-LRB- |
denotes |
( |
| T55 |
81-84 |
NN |
denotes |
IOP |
| T56 |
84-85 |
-RRB- |
denotes |
) |
| T57 |
86-88 |
IN |
denotes |
in |
| T58 |
89-93 |
NNS |
denotes |
mice |
| T59 |
94-97 |
CC |
denotes |
and |
| T60 |
98-103 |
JJ |
denotes |
other |
| T61 |
104-111 |
NNS |
denotes |
mammals |
| T62 |
111-112 |
. |
denotes |
. |
| T63 |
112-376 |
sentence |
denotes |
The purpose of this study was to determine the IOPs of genetically distinct mouse strains, assess the effects of factors such as age, sex and time of day on IOP in specific strain backgrounds, and to assess the effects of specific candidate gene mutations on IOP. |
| T64 |
113-116 |
DT |
denotes |
The |
| T65 |
117-124 |
NN |
denotes |
purpose |
| T66 |
139-142 |
VBD |
denotes |
was |
| T67 |
125-127 |
IN |
denotes |
of |
| T68 |
128-132 |
DT |
denotes |
this |
| T69 |
133-138 |
NN |
denotes |
study |
| T70 |
143-145 |
TO |
denotes |
to |
| T71 |
146-155 |
VB |
denotes |
determine |
| T72 |
156-159 |
DT |
denotes |
the |
| T73 |
160-164 |
NNS |
denotes |
IOPs |
| T74 |
165-167 |
IN |
denotes |
of |
| T75 |
168-179 |
RB |
denotes |
genetically |
| T76 |
180-188 |
JJ |
denotes |
distinct |
| T77 |
195-202 |
NNS |
denotes |
strains |
| T78 |
189-194 |
NN |
denotes |
mouse |
| T79 |
202-204 |
, |
denotes |
, |
| T80 |
204-210 |
VB |
denotes |
assess |
| T81 |
211-214 |
DT |
denotes |
the |
| T82 |
215-222 |
NNS |
denotes |
effects |
| T83 |
223-225 |
IN |
denotes |
of |
| T84 |
226-233 |
NNS |
denotes |
factors |
| T85 |
234-238 |
JJ |
denotes |
such |
| T86 |
239-241 |
IN |
denotes |
as |
| T87 |
242-245 |
NN |
denotes |
age |
| T88 |
245-247 |
, |
denotes |
, |
| T89 |
247-250 |
NN |
denotes |
sex |
| T90 |
251-254 |
CC |
denotes |
and |
| T91 |
255-259 |
NN |
denotes |
time |
| T92 |
260-262 |
IN |
denotes |
of |
| T93 |
263-266 |
NN |
denotes |
day |
| T94 |
267-269 |
IN |
denotes |
on |
| T95 |
270-273 |
NN |
denotes |
IOP |
| T96 |
274-276 |
IN |
denotes |
in |
| T97 |
277-285 |
JJ |
denotes |
specific |
| T98 |
293-304 |
NNS |
denotes |
backgrounds |
| T99 |
286-292 |
NN |
denotes |
strain |
| T100 |
304-306 |
, |
denotes |
, |
| T101 |
306-309 |
CC |
denotes |
and |
| T102 |
310-312 |
TO |
denotes |
to |
| T103 |
313-319 |
VB |
denotes |
assess |
| T104 |
320-323 |
DT |
denotes |
the |
| T105 |
324-331 |
NNS |
denotes |
effects |
| T106 |
332-334 |
IN |
denotes |
of |
| T107 |
335-343 |
JJ |
denotes |
specific |
| T108 |
359-368 |
NNS |
denotes |
mutations |
| T109 |
344-353 |
NN |
denotes |
candidate |
| T110 |
354-358 |
NN |
denotes |
gene |
| T111 |
369-371 |
IN |
denotes |
on |
| T112 |
372-375 |
NN |
denotes |
IOP |
| T113 |
375-376 |
. |
denotes |
. |
| T114 |
376-385 |
sentence |
denotes |
Results |
| T115 |
378-385 |
NNS |
denotes |
Results |
| T116 |
385-478 |
sentence |
denotes |
Based on over 30 studied mouse strains, average IOP ranges from approximately 10 to 20 mmHg. |
| T117 |
386-391 |
VBN |
denotes |
Based |
| T118 |
438-444 |
VBZ |
denotes |
ranges |
| T119 |
392-394 |
IN |
denotes |
on |
| T120 |
395-399 |
IN |
denotes |
over |
| T121 |
400-402 |
CD |
denotes |
30 |
| T122 |
417-424 |
NNS |
denotes |
strains |
| T123 |
403-410 |
VBN |
denotes |
studied |
| T124 |
411-416 |
NN |
denotes |
mouse |
| T125 |
424-426 |
, |
denotes |
, |
| T126 |
426-433 |
JJ |
denotes |
average |
| T127 |
434-437 |
NN |
denotes |
IOP |
| T128 |
445-449 |
IN |
denotes |
from |
| T129 |
450-463 |
RB |
denotes |
approximately |
| T130 |
464-466 |
CD |
denotes |
10 |
| T131 |
467-469 |
IN |
denotes |
to |
| T132 |
470-472 |
CD |
denotes |
20 |
| T133 |
473-477 |
NN |
denotes |
mmHg |
| T134 |
477-478 |
. |
denotes |
. |
| T135 |
478-569 |
sentence |
denotes |
Gender does not typically affect IOP and aging results in an IOP decrease in some strains. |
| T136 |
479-485 |
NN |
denotes |
Gender |
| T137 |
505-511 |
VB |
denotes |
affect |
| T138 |
486-490 |
VBZ |
denotes |
does |
| T139 |
491-494 |
RB |
denotes |
not |
| T140 |
495-504 |
RB |
denotes |
typically |
| T141 |
512-515 |
NN |
denotes |
IOP |
| T142 |
516-519 |
CC |
denotes |
and |
| T143 |
520-525 |
NN |
denotes |
aging |
| T144 |
526-533 |
VBZ |
denotes |
results |
| T145 |
534-536 |
IN |
denotes |
in |
| T146 |
537-539 |
DT |
denotes |
an |
| T147 |
544-552 |
NN |
denotes |
decrease |
| T148 |
540-543 |
NN |
denotes |
IOP |
| T149 |
553-555 |
IN |
denotes |
in |
| T150 |
556-560 |
DT |
denotes |
some |
| T151 |
561-568 |
NNS |
denotes |
strains |
| T152 |
568-569 |
. |
denotes |
. |
| T153 |
569-676 |
sentence |
denotes |
Most tested strains exhibit a diurnal rhythm with IOP being the highest during the dark period of the day. |
| T154 |
570-574 |
JJS |
denotes |
Most |
| T155 |
582-589 |
NNS |
denotes |
strains |
| T156 |
575-581 |
JJ |
denotes |
tested |
| T157 |
590-597 |
VBP |
denotes |
exhibit |
| T158 |
598-599 |
DT |
denotes |
a |
| T159 |
608-614 |
NN |
denotes |
rhythm |
| T160 |
600-607 |
JJ |
denotes |
diurnal |
| T161 |
615-619 |
IN |
denotes |
with |
| T162 |
620-623 |
NN |
denotes |
IOP |
| T163 |
624-629 |
VBG |
denotes |
being |
| T164 |
630-633 |
DT |
denotes |
the |
| T165 |
634-641 |
JJS |
denotes |
highest |
| T166 |
642-648 |
IN |
denotes |
during |
| T167 |
649-652 |
DT |
denotes |
the |
| T168 |
658-664 |
NN |
denotes |
period |
| T169 |
653-657 |
JJ |
denotes |
dark |
| T170 |
665-667 |
IN |
denotes |
of |
| T171 |
668-671 |
DT |
denotes |
the |
| T172 |
672-675 |
NN |
denotes |
day |
| T173 |
675-676 |
. |
denotes |
. |
| T174 |
676-898 |
sentence |
denotes |
Homozygosity for a null allele of the carbonic anhydrase II gene (Car2n) does not alter IOP while homozygosity for a mutation in the leptin receptor gene (Leprdb) that causes obesity and diabetes results in increased IOP. |
| T175 |
677-689 |
NN |
denotes |
Homozygosity |
| T176 |
759-764 |
VB |
denotes |
alter |
| T177 |
690-693 |
IN |
denotes |
for |
| T178 |
694-695 |
DT |
denotes |
a |
| T179 |
701-707 |
NN |
denotes |
allele |
| T180 |
696-700 |
JJ |
denotes |
null |
| T181 |
708-710 |
IN |
denotes |
of |
| T182 |
711-714 |
DT |
denotes |
the |
| T183 |
737-741 |
NN |
denotes |
gene |
| T184 |
715-723 |
JJ |
denotes |
carbonic |
| T185 |
724-733 |
NN |
denotes |
anhydrase |
| T186 |
734-736 |
CD |
denotes |
II |
| T187 |
742-743 |
-LRB- |
denotes |
( |
| T188 |
743-748 |
NN |
denotes |
Car2n |
| T189 |
748-749 |
-RRB- |
denotes |
) |
| T190 |
750-754 |
VBZ |
denotes |
does |
| T191 |
755-758 |
RB |
denotes |
not |
| T192 |
765-768 |
NN |
denotes |
IOP |
| T193 |
769-774 |
IN |
denotes |
while |
| T194 |
873-880 |
VBZ |
denotes |
results |
| T195 |
775-787 |
NN |
denotes |
homozygosity |
| T196 |
788-791 |
IN |
denotes |
for |
| T197 |
792-793 |
DT |
denotes |
a |
| T198 |
794-802 |
NN |
denotes |
mutation |
| T199 |
803-805 |
IN |
denotes |
in |
| T200 |
806-809 |
DT |
denotes |
the |
| T201 |
826-830 |
NN |
denotes |
gene |
| T202 |
810-816 |
NN |
denotes |
leptin |
| T203 |
817-825 |
NN |
denotes |
receptor |
| T204 |
831-832 |
-LRB- |
denotes |
( |
| T205 |
832-838 |
NN |
denotes |
Leprdb |
| T206 |
838-839 |
-RRB- |
denotes |
) |
| T207 |
840-844 |
WDT |
denotes |
that |
| T208 |
845-851 |
VBZ |
denotes |
causes |
| T209 |
852-859 |
NN |
denotes |
obesity |
| T210 |
860-863 |
CC |
denotes |
and |
| T211 |
864-872 |
NN |
denotes |
diabetes |
| T212 |
881-883 |
IN |
denotes |
in |
| T213 |
884-893 |
VBN |
denotes |
increased |
| T214 |
894-897 |
NN |
denotes |
IOP |
| T215 |
897-898 |
. |
denotes |
. |
| T216 |
898-1018 |
sentence |
denotes |
Albino C57BL/6J mice homozygous for a tyrosinase mutation (Tyrc-2J) have higher IOPs than their pigmented counterparts. |
| T217 |
899-905 |
NN |
denotes |
Albino |
| T218 |
915-919 |
NNS |
denotes |
mice |
| T219 |
906-911 |
NN |
denotes |
C57BL |
| T220 |
912-914 |
NN |
denotes |
6J |
| T221 |
911-912 |
HYPH |
denotes |
/ |
| T222 |
967-971 |
VBP |
denotes |
have |
| T223 |
920-930 |
JJ |
denotes |
homozygous |
| T224 |
931-934 |
IN |
denotes |
for |
| T225 |
935-936 |
DT |
denotes |
a |
| T226 |
948-956 |
NN |
denotes |
mutation |
| T227 |
937-947 |
NN |
denotes |
tyrosinase |
| T228 |
957-958 |
-LRB- |
denotes |
( |
| T229 |
958-962 |
NN |
denotes |
Tyrc |
| T230 |
963-965 |
NN |
denotes |
2J |
| T231 |
962-963 |
HYPH |
denotes |
- |
| T232 |
965-966 |
-RRB- |
denotes |
) |
| T233 |
972-978 |
JJR |
denotes |
higher |
| T234 |
979-983 |
NNS |
denotes |
IOPs |
| T235 |
984-988 |
IN |
denotes |
than |
| T236 |
989-994 |
PRP$ |
denotes |
their |
| T237 |
1005-1017 |
NNS |
denotes |
counterparts |
| T238 |
995-1004 |
JJ |
denotes |
pigmented |
| T239 |
1017-1018 |
. |
denotes |
. |
| T240 |
1018-1031 |
sentence |
denotes |
Conclusions |
| T241 |
1020-1031 |
NNS |
denotes |
Conclusions |
| T242 |
1031-1125 |
sentence |
denotes |
Genetically distinct mouse strains housed in the same environment have a broad range of IOPs. |
| T243 |
1032-1043 |
RB |
denotes |
Genetically |
| T244 |
1044-1052 |
JJ |
denotes |
distinct |
| T245 |
1059-1066 |
NNS |
denotes |
strains |
| T246 |
1053-1058 |
NN |
denotes |
mouse |
| T247 |
1098-1102 |
VBP |
denotes |
have |
| T248 |
1067-1073 |
VBN |
denotes |
housed |
| T249 |
1074-1076 |
IN |
denotes |
in |
| T250 |
1077-1080 |
DT |
denotes |
the |
| T251 |
1086-1097 |
NN |
denotes |
environment |
| T252 |
1081-1085 |
JJ |
denotes |
same |
| T253 |
1103-1104 |
DT |
denotes |
a |
| T254 |
1111-1116 |
NN |
denotes |
range |
| T255 |
1105-1110 |
JJ |
denotes |
broad |
| T256 |
1117-1119 |
IN |
denotes |
of |
| T257 |
1120-1124 |
NNS |
denotes |
IOPs |
| T258 |
1124-1125 |
. |
denotes |
. |
| T259 |
1125-1265 |
sentence |
denotes |
These IOP differences are likely due to interstrain genetic differences that create a powerful resource for studying the regulation of IOP. |
| T260 |
1126-1131 |
DT |
denotes |
These |
| T261 |
1136-1147 |
NNS |
denotes |
differences |
| T262 |
1132-1135 |
NNP |
denotes |
IOP |
| T263 |
1148-1151 |
VBP |
denotes |
are |
| T264 |
1152-1158 |
RB |
denotes |
likely |
| T265 |
1159-1162 |
IN |
denotes |
due |
| T266 |
1163-1165 |
IN |
denotes |
to |
| T267 |
1166-1177 |
JJ |
denotes |
interstrain |
| T268 |
1186-1197 |
NNS |
denotes |
differences |
| T269 |
1178-1185 |
JJ |
denotes |
genetic |
| T270 |
1198-1202 |
WDT |
denotes |
that |
| T271 |
1203-1209 |
VBP |
denotes |
create |
| T272 |
1210-1211 |
DT |
denotes |
a |
| T273 |
1221-1229 |
NN |
denotes |
resource |
| T274 |
1212-1220 |
JJ |
denotes |
powerful |
| T275 |
1230-1233 |
IN |
denotes |
for |
| T276 |
1234-1242 |
VBG |
denotes |
studying |
| T277 |
1243-1246 |
DT |
denotes |
the |
| T278 |
1247-1257 |
NN |
denotes |
regulation |
| T279 |
1258-1260 |
IN |
denotes |
of |
| T280 |
1261-1264 |
NN |
denotes |
IOP |
| T281 |
1264-1265 |
. |
denotes |
. |
| T282 |
1265-1376 |
sentence |
denotes |
Age, time of day, obesity and diabetes have effects on mouse IOP similar to those in humans and other species. |
| T283 |
1266-1269 |
NN |
denotes |
Age |
| T284 |
1305-1309 |
VBP |
denotes |
have |
| T285 |
1269-1271 |
, |
denotes |
, |
| T286 |
1271-1275 |
NN |
denotes |
time |
| T287 |
1276-1278 |
IN |
denotes |
of |
| T288 |
1279-1282 |
NN |
denotes |
day |
| T289 |
1282-1284 |
, |
denotes |
, |
| T290 |
1284-1291 |
NN |
denotes |
obesity |
| T291 |
1292-1295 |
CC |
denotes |
and |
| T292 |
1296-1304 |
NN |
denotes |
diabetes |
| T293 |
1310-1317 |
NNS |
denotes |
effects |
| T294 |
1318-1320 |
IN |
denotes |
on |
| T295 |
1321-1326 |
NN |
denotes |
mouse |
| T296 |
1327-1330 |
NN |
denotes |
IOP |
| T297 |
1331-1338 |
JJ |
denotes |
similar |
| T298 |
1339-1341 |
IN |
denotes |
to |
| T299 |
1342-1347 |
DT |
denotes |
those |
| T300 |
1348-1350 |
IN |
denotes |
in |
| T301 |
1351-1357 |
NNS |
denotes |
humans |
| T302 |
1358-1361 |
CC |
denotes |
and |
| T303 |
1362-1367 |
JJ |
denotes |
other |
| T304 |
1368-1375 |
NNS |
denotes |
species |
| T305 |
1375-1376 |
. |
denotes |
. |
| T306 |
1376-1465 |
sentence |
denotes |
Mutations in two of the assessed candidate genes (Lepr and Tyr) result in increased IOP. |
| T307 |
1377-1386 |
NNS |
denotes |
Mutations |
| T308 |
1441-1447 |
VBP |
denotes |
result |
| T309 |
1387-1389 |
IN |
denotes |
in |
| T310 |
1390-1393 |
CD |
denotes |
two |
| T311 |
1394-1396 |
IN |
denotes |
of |
| T312 |
1397-1400 |
DT |
denotes |
the |
| T313 |
1420-1425 |
NNS |
denotes |
genes |
| T314 |
1401-1409 |
VBN |
denotes |
assessed |
| T315 |
1410-1419 |
NN |
denotes |
candidate |
| T316 |
1426-1427 |
-LRB- |
denotes |
( |
| T317 |
1427-1431 |
NN |
denotes |
Lepr |
| T318 |
1432-1435 |
CC |
denotes |
and |
| T319 |
1436-1439 |
NN |
denotes |
Tyr |
| T320 |
1439-1440 |
-RRB- |
denotes |
) |
| T321 |
1448-1450 |
IN |
denotes |
in |
| T322 |
1451-1460 |
JJ |
denotes |
increased |
| T323 |
1461-1464 |
NN |
denotes |
IOP |
| T324 |
1464-1465 |
. |
denotes |
. |
| T325 |
1465-1646 |
sentence |
denotes |
These studies demonstrate that mice are a practical and powerful experimental system to study the genetics of IOP regulation and disease processes that raise IOP to harmful levels. |
| T326 |
1466-1471 |
DT |
denotes |
These |
| T327 |
1472-1479 |
NNS |
denotes |
studies |
| T328 |
1480-1491 |
VBP |
denotes |
demonstrate |
| T329 |
1492-1496 |
IN |
denotes |
that |
| T330 |
1502-1505 |
VBP |
denotes |
are |
| T331 |
1497-1501 |
NNS |
denotes |
mice |
| T332 |
1506-1507 |
DT |
denotes |
a |
| T333 |
1544-1550 |
NN |
denotes |
system |
| T334 |
1508-1517 |
JJ |
denotes |
practical |
| T335 |
1518-1521 |
CC |
denotes |
and |
| T336 |
1522-1530 |
JJ |
denotes |
powerful |
| T337 |
1531-1543 |
JJ |
denotes |
experimental |
| T338 |
1551-1553 |
TO |
denotes |
to |
| T339 |
1554-1559 |
VB |
denotes |
study |
| T340 |
1560-1563 |
DT |
denotes |
the |
| T341 |
1564-1572 |
NN |
denotes |
genetics |
| T342 |
1573-1575 |
IN |
denotes |
of |
| T343 |
1576-1579 |
NN |
denotes |
IOP |
| T344 |
1580-1590 |
NN |
denotes |
regulation |
| T345 |
1591-1594 |
CC |
denotes |
and |
| T346 |
1595-1602 |
NN |
denotes |
disease |
| T347 |
1603-1612 |
NNS |
denotes |
processes |
| T348 |
1613-1617 |
WDT |
denotes |
that |
| T349 |
1618-1623 |
VBP |
denotes |
raise |
| T350 |
1624-1627 |
NN |
denotes |
IOP |
| T351 |
1628-1630 |
IN |
denotes |
to |
| T352 |
1631-1638 |
JJ |
denotes |
harmful |
| T353 |
1639-1645 |
NNS |
denotes |
levels |
| T354 |
1645-1646 |
. |
denotes |
. |
| R41 |
T77 |
T74 |
pobj |
strains,of |
| R42 |
T78 |
T77 |
compound |
mouse,strains |
| R62 |
T98 |
T96 |
pobj |
backgrounds,in |
| R63 |
T99 |
T98 |
compound |
strain,backgrounds |
| R72 |
T108 |
T106 |
pobj |
mutations,of |
| R73 |
T109 |
T108 |
compound |
candidate,mutations |
| R74 |
T110 |
T108 |
compound |
gene,mutations |
| R82 |
T122 |
T119 |
pobj |
strains,on |
| R83 |
T123 |
T122 |
amod |
studied,strains |
| R84 |
T124 |
T122 |
compound |
mouse,strains |
| R105 |
T147 |
T145 |
pobj |
decrease,in |
| R106 |
T148 |
T147 |
compound |
IOP,decrease |
| R112 |
T155 |
T157 |
nsubj |
strains,exhibit |
| R113 |
T156 |
T155 |
amod |
tested,strains |
| R115 |
T159 |
T157 |
dobj |
rhythm,exhibit |
| R116 |
T160 |
T159 |
amod |
diurnal,rhythm |
| R124 |
T168 |
T166 |
pobj |
period,during |
| R125 |
T169 |
T168 |
amod |
dark,period |
| R133 |
T179 |
T177 |
pobj |
allele,for |
| R134 |
T180 |
T179 |
amod |
null,allele |
| R137 |
T183 |
T181 |
pobj |
gene,of |
| R138 |
T184 |
T183 |
amod |
carbonic,gene |
| R139 |
T185 |
T183 |
nmod |
anhydrase,gene |
| R140 |
T186 |
T183 |
nummod |
II,gene |
| R148 |
T194 |
T176 |
advcl |
results,alter |
| R149 |
T195 |
T194 |
nsubj |
homozygosity,results |
| R150 |
T196 |
T195 |
prep |
for,homozygosity |
| R151 |
T197 |
T198 |
det |
a,mutation |
| R152 |
T198 |
T196 |
pobj |
mutation,for |
| R153 |
T199 |
T198 |
prep |
in,mutation |
| R154 |
T200 |
T201 |
det |
the,gene |
| R155 |
T201 |
T199 |
pobj |
gene,in |
| R156 |
T202 |
T201 |
compound |
leptin,gene |
| R157 |
T203 |
T201 |
compound |
receptor,gene |
| R158 |
T204 |
T201 |
punct |
(,gene |
| R159 |
T205 |
T201 |
appos |
Leprdb,gene |
| R160 |
T206 |
T198 |
punct |
),mutation |
| R161 |
T207 |
T208 |
dep |
that,causes |
| R162 |
T208 |
T198 |
relcl |
causes,mutation |
| R163 |
T209 |
T208 |
dobj |
obesity,causes |
| R164 |
T210 |
T209 |
cc |
and,obesity |
| R165 |
T211 |
T209 |
conj |
diabetes,obesity |
| R171 |
T218 |
T222 |
nsubj |
mice,have |
| R172 |
T219 |
T220 |
compound |
C57BL,6J |
| R174 |
T221 |
T220 |
punct |
/,6J |
| R178 |
T226 |
T224 |
pobj |
mutation,for |
| R179 |
T227 |
T226 |
compound |
tyrosinase,mutation |
| R182 |
T230 |
T226 |
appos |
2J,mutation |
| R183 |
T231 |
T230 |
punct |
-,2J |
| R189 |
T237 |
T235 |
pobj |
counterparts,than |
| R190 |
T238 |
T237 |
amod |
pigmented,counterparts |
| R194 |
T245 |
T247 |
nsubj |
strains,have |
| R195 |
T246 |
T245 |
compound |
mouse,strains |
| R199 |
T251 |
T249 |
pobj |
environment,in |
| R200 |
T252 |
T251 |
amod |
same,environment |
| R202 |
T254 |
T247 |
dobj |
range,have |
| R203 |
T255 |
T254 |
amod |
broad,range |
| R208 |
T261 |
T263 |
nsubj |
differences,are |
| R209 |
T262 |
T261 |
compound |
IOP,differences |
| R214 |
T268 |
T265 |
pobj |
differences,due |
| R215 |
T269 |
T268 |
amod |
genetic,differences |
| R219 |
T273 |
T271 |
dobj |
resource,create |
| R220 |
T274 |
T273 |
amod |
powerful,resource |
| R255 |
T313 |
T311 |
pobj |
genes,of |
| R256 |
T314 |
T313 |
amod |
assessed,genes |
| R257 |
T315 |
T313 |
compound |
candidate,genes |
| R270 |
T330 |
T328 |
ccomp |
are,demonstrate |
| R271 |
T331 |
T330 |
nsubj |
mice,are |
| R273 |
T333 |
T330 |
attr |
system,are |
| R274 |
T334 |
T333 |
amod |
practical,system |
| R275 |
T335 |
T334 |
cc |
and,practical |
| R276 |
T336 |
T334 |
conj |
powerful,practical |
| R277 |
T337 |
T333 |
amod |
experimental,system |
| R29 |
T64 |
T65 |
det |
The,purpose |
| R30 |
T65 |
T66 |
nsubj |
purpose,was |
| R31 |
T67 |
T65 |
prep |
of,purpose |
| R32 |
T68 |
T69 |
det |
this,study |
| R33 |
T69 |
T67 |
pobj |
study,of |
| R34 |
T70 |
T71 |
aux |
to,determine |
| R35 |
T71 |
T66 |
ccomp |
determine,was |
| R36 |
T72 |
T73 |
det |
the,IOPs |
| R37 |
T73 |
T71 |
dobj |
IOPs,determine |
| R38 |
T74 |
T73 |
prep |
of,IOPs |
| R39 |
T75 |
T76 |
advmod |
genetically,distinct |
| R40 |
T76 |
T77 |
amod |
distinct,strains |
| R43 |
T79 |
T71 |
punct |
", ",determine |
| R44 |
T80 |
T71 |
dep |
assess,determine |
| R45 |
T81 |
T82 |
det |
the,effects |
| R46 |
T82 |
T80 |
dobj |
effects,assess |
| R47 |
T83 |
T82 |
prep |
of,effects |
| R48 |
T84 |
T83 |
pobj |
factors,of |
| R49 |
T85 |
T86 |
amod |
such,as |
| R50 |
T86 |
T84 |
prep |
as,factors |
| R51 |
T87 |
T86 |
pobj |
age,as |
| R52 |
T88 |
T87 |
punct |
", ",age |
| R53 |
T89 |
T87 |
conj |
sex,age |
| R54 |
T90 |
T89 |
cc |
and,sex |
| R55 |
T91 |
T89 |
conj |
time,sex |
| R56 |
T92 |
T91 |
prep |
of,time |
| R57 |
T93 |
T92 |
pobj |
day,of |
| R58 |
T94 |
T82 |
prep |
on,effects |
| R59 |
T95 |
T94 |
pobj |
IOP,on |
| R60 |
T96 |
T95 |
prep |
in,IOP |
| R61 |
T97 |
T98 |
amod |
specific,backgrounds |
| R64 |
T100 |
T71 |
punct |
", ",determine |
| R65 |
T101 |
T71 |
cc |
and,determine |
| R66 |
T102 |
T103 |
aux |
to,assess |
| R67 |
T103 |
T71 |
conj |
assess,determine |
| R68 |
T104 |
T105 |
det |
the,effects |
| R69 |
T105 |
T103 |
dobj |
effects,assess |
| R70 |
T106 |
T105 |
prep |
of,effects |
| R71 |
T107 |
T108 |
amod |
specific,mutations |
| R75 |
T111 |
T105 |
prep |
on,effects |
| R76 |
T112 |
T111 |
pobj |
IOP,on |
| R77 |
T113 |
T66 |
punct |
.,was |
| R78 |
T117 |
T118 |
prep |
Based,ranges |
| R79 |
T119 |
T117 |
prep |
on,Based |
| R80 |
T120 |
T121 |
quantmod |
over,30 |
| R81 |
T121 |
T122 |
nummod |
30,strains |
| R85 |
T125 |
T118 |
punct |
", ",ranges |
| R86 |
T126 |
T127 |
amod |
average,IOP |
| R87 |
T127 |
T118 |
nsubj |
IOP,ranges |
| R88 |
T128 |
T118 |
prep |
from,ranges |
| R89 |
T129 |
T130 |
advmod |
approximately,10 |
| R90 |
T130 |
T128 |
pobj |
10,from |
| R91 |
T131 |
T128 |
prep |
to,from |
| R92 |
T132 |
T131 |
pobj |
20,to |
| R93 |
T133 |
T128 |
pobj |
mmHg,from |
| R94 |
T134 |
T118 |
punct |
.,ranges |
| R95 |
T136 |
T137 |
nsubj |
Gender,affect |
| R96 |
T138 |
T137 |
aux |
does,affect |
| R97 |
T139 |
T137 |
neg |
not,affect |
| R98 |
T140 |
T137 |
advmod |
typically,affect |
| R99 |
T141 |
T137 |
dobj |
IOP,affect |
| R100 |
T142 |
T137 |
cc |
and,affect |
| R101 |
T143 |
T144 |
nsubj |
aging,results |
| R102 |
T144 |
T137 |
conj |
results,affect |
| R103 |
T145 |
T144 |
prep |
in,results |
| R104 |
T146 |
T147 |
det |
an,decrease |
| R107 |
T149 |
T144 |
prep |
in,results |
| R108 |
T150 |
T151 |
det |
some,strains |
| R109 |
T151 |
T149 |
pobj |
strains,in |
| R110 |
T152 |
T144 |
punct |
.,results |
| R111 |
T154 |
T155 |
amod |
Most,strains |
| R114 |
T158 |
T159 |
det |
a,rhythm |
| R117 |
T161 |
T157 |
prep |
with,exhibit |
| R118 |
T162 |
T163 |
nsubj |
IOP,being |
| R119 |
T163 |
T161 |
pcomp |
being,with |
| R120 |
T164 |
T165 |
advmod |
the,highest |
| R121 |
T165 |
T163 |
acomp |
highest,being |
| R122 |
T166 |
T163 |
prep |
during,being |
| R123 |
T167 |
T168 |
det |
the,period |
| R126 |
T170 |
T168 |
prep |
of,period |
| R127 |
T171 |
T172 |
det |
the,day |
| R128 |
T172 |
T170 |
pobj |
day,of |
| R129 |
T173 |
T157 |
punct |
.,exhibit |
| R130 |
T175 |
T176 |
nsubj |
Homozygosity,alter |
| R131 |
T177 |
T175 |
prep |
for,Homozygosity |
| R132 |
T178 |
T179 |
det |
a,allele |
| R135 |
T181 |
T179 |
prep |
of,allele |
| R136 |
T182 |
T183 |
det |
the,gene |
| R141 |
T187 |
T183 |
punct |
(,gene |
| R142 |
T188 |
T183 |
appos |
Car2n,gene |
| R143 |
T189 |
T176 |
punct |
),alter |
| R144 |
T190 |
T176 |
aux |
does,alter |
| R145 |
T191 |
T176 |
neg |
not,alter |
| R146 |
T192 |
T176 |
dobj |
IOP,alter |
| R147 |
T193 |
T194 |
mark |
while,results |
| R166 |
T212 |
T194 |
prep |
in,results |
| R167 |
T213 |
T214 |
amod |
increased,IOP |
| R168 |
T214 |
T212 |
pobj |
IOP,in |
| R169 |
T215 |
T176 |
punct |
.,alter |
| R170 |
T217 |
T218 |
compound |
Albino,mice |
| R173 |
T220 |
T218 |
compound |
6J,mice |
| R175 |
T223 |
T218 |
amod |
homozygous,mice |
| R176 |
T224 |
T223 |
prep |
for,homozygous |
| R177 |
T225 |
T226 |
det |
a,mutation |
| R180 |
T228 |
T226 |
punct |
(,mutation |
| R181 |
T229 |
T230 |
compound |
Tyrc,2J |
| R184 |
T232 |
T222 |
punct |
),have |
| R185 |
T233 |
T234 |
amod |
higher,IOPs |
| R186 |
T234 |
T222 |
dobj |
IOPs,have |
| R187 |
T235 |
T234 |
prep |
than,IOPs |
| R188 |
T236 |
T237 |
poss |
their,counterparts |
| R191 |
T239 |
T222 |
punct |
.,have |
| R192 |
T243 |
T244 |
advmod |
Genetically,distinct |
| R193 |
T244 |
T245 |
amod |
distinct,strains |
| R196 |
T248 |
T245 |
acl |
housed,strains |
| R197 |
T249 |
T248 |
prep |
in,housed |
| R198 |
T250 |
T251 |
det |
the,environment |
| R201 |
T253 |
T254 |
det |
a,range |
| R204 |
T256 |
T254 |
prep |
of,range |
| R205 |
T257 |
T256 |
pobj |
IOPs,of |
| R206 |
T258 |
T247 |
punct |
.,have |
| R207 |
T260 |
T261 |
det |
These,differences |
| R210 |
T264 |
T263 |
advmod |
likely,are |
| R211 |
T265 |
T263 |
prep |
due,are |
| R212 |
T266 |
T265 |
pcomp |
to,due |
| R213 |
T267 |
T268 |
amod |
interstrain,differences |
| R216 |
T270 |
T271 |
dep |
that,create |
| R217 |
T271 |
T268 |
relcl |
create,differences |
| R218 |
T272 |
T273 |
det |
a,resource |
| R221 |
T275 |
T271 |
prep |
for,create |
| R222 |
T276 |
T275 |
pcomp |
studying,for |
| R223 |
T277 |
T278 |
det |
the,regulation |
| R224 |
T278 |
T276 |
dobj |
regulation,studying |
| R225 |
T279 |
T278 |
prep |
of,regulation |
| R226 |
T280 |
T279 |
pobj |
IOP,of |
| R227 |
T281 |
T263 |
punct |
.,are |
| R228 |
T283 |
T284 |
nsubj |
Age,have |
| R229 |
T285 |
T283 |
punct |
", ",Age |
| R230 |
T286 |
T283 |
conj |
time,Age |
| R231 |
T287 |
T286 |
prep |
of,time |
| R232 |
T288 |
T287 |
pobj |
day,of |
| R233 |
T289 |
T286 |
punct |
", ",time |
| R234 |
T290 |
T286 |
conj |
obesity,time |
| R235 |
T291 |
T290 |
cc |
and,obesity |
| R236 |
T292 |
T290 |
conj |
diabetes,obesity |
| R237 |
T293 |
T284 |
dobj |
effects,have |
| R238 |
T294 |
T293 |
prep |
on,effects |
| R239 |
T295 |
T296 |
compound |
mouse,IOP |
| R240 |
T296 |
T294 |
pobj |
IOP,on |
| R241 |
T297 |
T293 |
amod |
similar,effects |
| R242 |
T298 |
T297 |
prep |
to,similar |
| R243 |
T299 |
T298 |
pobj |
those,to |
| R244 |
T300 |
T299 |
prep |
in,those |
| R245 |
T301 |
T300 |
pobj |
humans,in |
| R246 |
T302 |
T301 |
cc |
and,humans |
| R247 |
T303 |
T304 |
amod |
other,species |
| R248 |
T304 |
T301 |
conj |
species,humans |
| R249 |
T305 |
T284 |
punct |
.,have |
| R250 |
T307 |
T308 |
nsubj |
Mutations,result |
| R251 |
T309 |
T307 |
prep |
in,Mutations |
| R252 |
T310 |
T309 |
pobj |
two,in |
| R253 |
T311 |
T310 |
prep |
of,two |
| R254 |
T312 |
T313 |
det |
the,genes |
| R258 |
T316 |
T310 |
punct |
(,two |
| R259 |
T317 |
T310 |
appos |
Lepr,two |
| R260 |
T318 |
T317 |
cc |
and,Lepr |
| R261 |
T319 |
T317 |
conj |
Tyr,Lepr |
| R262 |
T320 |
T308 |
punct |
),result |
| R263 |
T321 |
T308 |
prep |
in,result |
| R264 |
T322 |
T323 |
amod |
increased,IOP |
| R265 |
T323 |
T321 |
pobj |
IOP,in |
| R266 |
T324 |
T308 |
punct |
.,result |
| R267 |
T326 |
T327 |
det |
These,studies |
| R268 |
T327 |
T328 |
nsubj |
studies,demonstrate |
| R269 |
T329 |
T330 |
mark |
that,are |
| R272 |
T332 |
T333 |
det |
a,system |
| R278 |
T338 |
T339 |
aux |
to,study |
| R279 |
T339 |
T333 |
advcl |
study,system |
| R280 |
T340 |
T341 |
det |
the,genetics |
| R281 |
T341 |
T339 |
dobj |
genetics,study |
| R282 |
T342 |
T341 |
prep |
of,genetics |
| R283 |
T343 |
T344 |
compound |
IOP,regulation |
| R284 |
T344 |
T342 |
pobj |
regulation,of |
| R285 |
T345 |
T344 |
cc |
and,regulation |
| R286 |
T346 |
T347 |
compound |
disease,processes |
| R287 |
T347 |
T344 |
conj |
processes,regulation |
| R288 |
T348 |
T349 |
dep |
that,raise |
| R289 |
T349 |
T344 |
relcl |
raise,regulation |
| R290 |
T350 |
T349 |
dobj |
IOP,raise |
| R291 |
T351 |
T349 |
prep |
to,raise |
| R292 |
T352 |
T353 |
amod |
harmful,levels |
| R293 |
T353 |
T351 |
pobj |
levels,to |
| R294 |
T354 |
T328 |
punct |
.,demonstrate |
| R12 |
T45 |
T46 |
nsubjpass |
Little,known |
| R13 |
T47 |
T46 |
auxpass |
is,known |
| R14 |
T48 |
T46 |
prep |
about,known |
| R15 |
T49 |
T50 |
amod |
genetic,factors |
| R16 |
T50 |
T48 |
pobj |
factors,about |
| R17 |
T51 |
T50 |
acl |
affecting,factors |
| R18 |
T52 |
T53 |
amod |
intraocular,pressure |
| R19 |
T53 |
T51 |
dobj |
pressure,affecting |
| R20 |
T54 |
T55 |
punct |
(,IOP |
| R21 |
T55 |
T53 |
appos |
IOP,pressure |
| R22 |
T56 |
T53 |
punct |
),pressure |
| R23 |
T57 |
T53 |
prep |
in,pressure |
| R24 |
T58 |
T57 |
pobj |
mice,in |
| R25 |
T59 |
T58 |
cc |
and,mice |
| R26 |
T60 |
T61 |
amod |
other,mammals |
| R27 |
T61 |
T58 |
conj |
mammals,mice |
| R28 |
T62 |
T46 |
punct |
.,known |