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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4719559","sourcedb":"PMC","sourceid":"4719559","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4719559","text":"Diet\nDuring the 9-day adaptation periods, recovery periods, as well as during the normocaloric ambulatory intervention, the participants received a normocaloric standard diet. During the intervention periods, energy requirements were calculated for each individual according to the Food and Agriculture Organization of the United Nations and World Health Organization (FAO/WHO) equations [19] as described previously [17]. Briefly, during normocaloric conditions, participants received a diet containing 1.4 (ambulatory) or 1.1 (bedrest) times their basal metabolic rate (BMR). During hypocaloric conditions, participants received a diet containing 1.1 (ambulatory) and 0.9 (bedrest) times BMR. Ten percent of the total calories was added to account for dietary-induced thermogenesis. Dietary protein, fat (saturated and polyunsaturated fatty acids), and carbohydrate intakes were calculated according to dietary reference intake values [20] (i.e., 1.0 g/kg body mass/day as protein, 30 % as fat, and the remaining part as carbohydrates). Protein intake was kept constant during all study phases. Reduction in energy intake was mainly achieved by reduction of fat intake to a minimum level of 60 g/day in order to keep the recommended level of essential fatty acids. The remaining energy was composed of carbohydrates. Total energy and nutrient intake for all four phases has been reported previously [21].","divisions":[{"label":"title","span":{"begin":0,"end":4}}],"tracks":[{"project":"TEST0","denotations":[{"id":"26793301-213-219-73089","span":{"begin":389,"end":391},"obj":"[\"12600854\"]"},{"id":"26793301-153-159-73090","span":{"begin":938,"end":940},"obj":"[\"9627630\"]"},{"id":"26793301-83-89-73091","span":{"begin":1402,"end":1404},"obj":"[\"17684207\"]"}],"attributes":[{"subj":"26793301-213-219-73089","pred":"source","obj":"TEST0"},{"subj":"26793301-153-159-73090","pred":"source","obj":"TEST0"},{"subj":"26793301-83-89-73091","pred":"source","obj":"TEST0"}]},{"project":"MyTest","denotations":[{"id":"26793301-12600854-30256708","span":{"begin":389,"end":391},"obj":"12600854"},{"id":"26793301-9627630-30256709","span":{"begin":938,"end":940},"obj":"9627630"},{"id":"26793301-17684207-30256710","span":{"begin":1402,"end":1404},"obj":"17684207"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"26793301-12600854-30256708","pred":"source","obj":"MyTest"},{"subj":"26793301-9627630-30256709","pred":"source","obj":"MyTest"},{"subj":"26793301-17684207-30256710","pred":"source","obj":"MyTest"}]},{"project":"0_colil","denotations":[{"id":"26793301-12600854-73089","span":{"begin":389,"end":391},"obj":"12600854"},{"id":"26793301-9627630-73090","span":{"begin":938,"end":940},"obj":"9627630"},{"id":"26793301-17684207-73091","span":{"begin":1402,"end":1404},"obj":"17684207"}],"attributes":[{"subj":"26793301-12600854-73089","pred":"source","obj":"0_colil"},{"subj":"26793301-9627630-73090","pred":"source","obj":"0_colil"},{"subj":"26793301-17684207-73091","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"26793301-12600854-30256708","span":{"begin":389,"end":391},"obj":"12600854"},{"id":"26793301-9627630-30256709","span":{"begin":938,"end":940},"obj":"9627630"},{"id":"26793301-17684207-30256710","span":{"begin":1402,"end":1404},"obj":"17684207"}],"attributes":[{"subj":"26793301-12600854-30256708","pred":"source","obj":"2_test"},{"subj":"26793301-9627630-30256709","pred":"source","obj":"2_test"},{"subj":"26793301-17684207-30256710","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#93ecd8","default":true},{"id":"MyTest","color":"#ecbe93"},{"id":"0_colil","color":"#a493ec"},{"id":"2_test","color":"#9cec93"}]}]}}