PMC:4719559 / 6652-7766 JSONTXT

{"project":"TEST0","denotations":[{"id":"26793301-93-99-73088","span":{"begin":555,"end":557},"obj":"[\"438025\"]"}],"text":"The participants resided in a metabolic ward (Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany) during the entire period of the four interventions. Room temperature and relative humidity were kept constant (24 °C and 50 %) in the laboratory and metabolic ward. During the bedrest phases, all activities, including food intake, showering, using the toilet, and weighing, were carried out in the 6° head-down-tilt or horizontal position. 6° head-down-tilt was chosen because it is a validated model for simulation of microgravity [18]. Though the induced cardiovascular changes from the 6° head-down position occur more rapidly, their nature and extent are very similar to those observed in supine position. During the ambulatory control phases, the participants maintained upright position during the day and were allowed to walk around in the ward. Although they were not allowed to exercise voluntarily, they followed a light exercise protocol (including bicycle ergometry ~125 W for 15 min twice/day), a load sufficiently light to likely not have a significant impact on energy balance."}

{"project":"MyTest","denotations":[{"id":"26793301-438025-30256707","span":{"begin":555,"end":557},"obj":"438025"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"The participants resided in a metabolic ward (Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany) during the entire period of the four interventions. Room temperature and relative humidity were kept constant (24 °C and 50 %) in the laboratory and metabolic ward. During the bedrest phases, all activities, including food intake, showering, using the toilet, and weighing, were carried out in the 6° head-down-tilt or horizontal position. 6° head-down-tilt was chosen because it is a validated model for simulation of microgravity [18]. Though the induced cardiovascular changes from the 6° head-down position occur more rapidly, their nature and extent are very similar to those observed in supine position. During the ambulatory control phases, the participants maintained upright position during the day and were allowed to walk around in the ward. Although they were not allowed to exercise voluntarily, they followed a light exercise protocol (including bicycle ergometry ~125 W for 15 min twice/day), a load sufficiently light to likely not have a significant impact on energy balance."}

{"project":"0_colil","denotations":[{"id":"26793301-438025-73088","span":{"begin":555,"end":557},"obj":"438025"}],"text":"The participants resided in a metabolic ward (Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany) during the entire period of the four interventions. Room temperature and relative humidity were kept constant (24 °C and 50 %) in the laboratory and metabolic ward. During the bedrest phases, all activities, including food intake, showering, using the toilet, and weighing, were carried out in the 6° head-down-tilt or horizontal position. 6° head-down-tilt was chosen because it is a validated model for simulation of microgravity [18]. Though the induced cardiovascular changes from the 6° head-down position occur more rapidly, their nature and extent are very similar to those observed in supine position. During the ambulatory control phases, the participants maintained upright position during the day and were allowed to walk around in the ward. Although they were not allowed to exercise voluntarily, they followed a light exercise protocol (including bicycle ergometry ~125 W for 15 min twice/day), a load sufficiently light to likely not have a significant impact on energy balance."}

{"project":"2_test","denotations":[{"id":"26793301-438025-30256707","span":{"begin":555,"end":557},"obj":"438025"}],"text":"The participants resided in a metabolic ward (Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany) during the entire period of the four interventions. Room temperature and relative humidity were kept constant (24 °C and 50 %) in the laboratory and metabolic ward. During the bedrest phases, all activities, including food intake, showering, using the toilet, and weighing, were carried out in the 6° head-down-tilt or horizontal position. 6° head-down-tilt was chosen because it is a validated model for simulation of microgravity [18]. Though the induced cardiovascular changes from the 6° head-down position occur more rapidly, their nature and extent are very similar to those observed in supine position. During the ambulatory control phases, the participants maintained upright position during the day and were allowed to walk around in the ward. Although they were not allowed to exercise voluntarily, they followed a light exercise protocol (including bicycle ergometry ~125 W for 15 min twice/day), a load sufficiently light to likely not have a significant impact on energy balance."}