PMC:4719559 / 3919-4856 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4719559","sourcedb":"PMC","sourceid":"4719559","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4719559","text":"Subjects\nNine healthy men (age: 23.8 ± 3.0 years; BMI: 22.8 ± 3.2 kg/m2) completed a randomized crossover bedrest and caloric restriction study to simulate the effects of spaceflight. Approval for the project was obtained from the Ethical Committee of the ‘Arztekammer Nordrhein,’ Dusseldorf, Germany. Each subject gave written informed consent, and all procedures conformed to the Declaration of Helsinki. Subjects were enrolled if they met all of the following inclusion criteria: physical examination, ECG, urinalysis, and routine laboratory without clinically relevant findings, total cholesterol ≤200 mg/dL, LDL ≤130 mg/dL, HDL ≥35 mg/dL, and fasting glucose ≤106 mg/dL. Exclusion criteria included hyperlipidemia, arterial hypertension, diabetes, regular medication, and/or treatment with drugs within the last 6 weeks, acute or chronic illness, smoking within a period of 1 year preceding the study, and drug and/or alcohol abuse.","divisions":[{"label":"title","span":{"begin":0,"end":8}}],"tracks":[]}