PMC:4718081 / 6218-7582
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4718081","sourcedb":"PMC","sourceid":"4718081","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4718081","text":"Subject\nData used in the preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). The initial goal of ADNI was to recruit 800 subjects but ADNI has been followed by ADNI-GO and ADNI-2. To date these three protocols have recruited over 1500 adults, ages 55–90, to participate in the research, consisting of cognitively normal older individuals, people with early or late MCI, and people with early AD. For up-to-date information, see http://www.adni-info.org.\nIn this study, the longitudinal biomarker data (4 years, version: 2012-09-06) in ADNI-1 is used to develop the model. The data set includes three CSF markers: Tau protein, Aβ, and Phosphorylated tau protein (P-tau). Details of the CSF analysis and quality control measures have previously been published (Shaw et al., 2009). The patients are divided into three groups: AD, MCI, and normal control group. The CSF samples are collected at four time points: 12, 24, 36, and 48 months. Patients with missing data are excluded in our experiments. The demographic information of subjects used in this study at different time points is given in Table 1.\nTable 1 Demographic information of subjects.\nNormal MCI AD\nNumber 135 155 18\nGender (male/female) 71/60 106/49 6/12\nAge 79 ± 5 77 ± 6 74 ± 7\nMMSE 29 ± 1 27 ± 2 24 ± 2","divisions":[{"label":"title","span":{"begin":0,"end":7}},{"label":"p","span":{"begin":8,"end":533}},{"label":"p","span":{"begin":534,"end":1180}},{"label":"label","span":{"begin":1181,"end":1188}},{"label":"caption","span":{"begin":1190,"end":1226}},{"label":"p","span":{"begin":1190,"end":1226}},{"label":"tr","span":{"begin":1227,"end":1244}},{"label":"th","span":{"begin":1227,"end":1234}},{"label":"th","span":{"begin":1235,"end":1239}},{"label":"th","span":{"begin":1241,"end":1244}},{"label":"tr","span":{"begin":1245,"end":1265}},{"label":"td","span":{"begin":1245,"end":1251}},{"label":"td","span":{"begin":1253,"end":1256}},{"label":"td","span":{"begin":1258,"end":1261}},{"label":"td","span":{"begin":1263,"end":1265}},{"label":"tr","span":{"begin":1266,"end":1307}},{"label":"td","span":{"begin":1266,"end":1286}},{"label":"td","span":{"begin":1288,"end":1293}},{"label":"td","span":{"begin":1295,"end":1301}},{"label":"td","span":{"begin":1303,"end":1307}},{"label":"tr","span":{"begin":1308,"end":1335}},{"label":"td","span":{"begin":1308,"end":1311}},{"label":"td","span":{"begin":1313,"end":1319}},{"label":"td","span":{"begin":1321,"end":1327}},{"label":"td","span":{"begin":1329,"end":1335}},{"label":"td","span":{"begin":1336,"end":1340}},{"label":"td","span":{"begin":1342,"end":1348}},{"label":"td","span":{"begin":1350,"end":1356}}],"tracks":[{"project":"TEST0","denotations":[{"id":"26834548-102-110-278847","span":{"begin":852,"end":856},"obj":"[\"19296504\"]"}],"attributes":[{"subj":"26834548-102-110-278847","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"26834548-19296504-278847","span":{"begin":852,"end":856},"obj":"19296504"}],"attributes":[{"subj":"26834548-19296504-278847","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"26834548-19296504-38218437","span":{"begin":852,"end":856},"obj":"19296504"}],"attributes":[{"subj":"26834548-19296504-38218437","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#a4ec93","default":true},{"id":"0_colil","color":"#ec93be"},{"id":"2_test","color":"#93d8ec"}]}]}}