PMC:4718081 / 5324-6194 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4718081","sourcedb":"PMC","sourceid":"4718081","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4718081","text":"The aim of this research is to provide novel insight into the progression from the perspective of crosstalk network disruption. Nevertheless, cross-talk network is a large complicated system, evaluating the entire network robustness is less practical. To address this issue, a simplified cross-talk network termed as mini network is established. The widely accepted key markers are selected to form the skeleton of the mini network. The cross-talk among key markers is modeled by transit compartments model. Robustness and the integral variation of the mini network are proposed to be used as a good proxy for complex disease progression. In our model, three mini network integral disruption parameters U, K, and φ are introduced to evaluate integral variation of the network and mini network disruption probability is employed to measure the robustness of mini network.","tracks":[]}