PMC:4718081 / 23524-24762
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4718081","sourcedb":"PMC","sourceid":"4718081","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4718081","text":"Furthermore, more and more evidences in clinical trials suggest the multifactorial nature of AD. For example, Anti-bodies bapineuzumab and solanezumab targeted at Aβ have failed to meet their primary endpoints in the high-profile phase 3 clinical trials (Castello et al., 2014). Doody et al. attribute the failure to administering the therapy at late stages and propose that it should be instituted in early stages (Doody et al., 2014). However, the proposed model suggests that even at early stage the therapies targeted at Aβ only may have limited effect on AD. The presented results suggest that P-tau may also play a vital role in AD progression. Several prior studies have proved that immunotherapies targeted at P-tau can reduce cognitive impairment in animal model (Boutajangout et al., 2010; Kayed, 2010; Lim et al., 2013). In addition, our results suggested that single marker might play a limited role in disease progression and joint contribution of P-tau and Aβ might be the potential vital factors in the disease progression. Therefore, the single-target immunotherapies may have limited effects on AD. According to our results, combination therapy of reducing both P-tau and Aβ may be an effective strategy for AD treatment.","tracks":[{"project":"TEST0","denotations":[{"id":"26834548-175-183-278867","span":{"begin":272,"end":276},"obj":"[\"25179671\"]"},{"id":"26834548-151-159-278868","span":{"begin":430,"end":434},"obj":"[\"24450890\"]"},{"id":"26834548-143-151-278869","span":{"begin":794,"end":798},"obj":"[\"21147995\"]"},{"id":"26834548-156-164-278870","span":{"begin":807,"end":811},"obj":"[\"20980799\"]"},{"id":"26834548-174-182-278871","span":{"begin":825,"end":829},"obj":"[\"24176981\"]"}],"attributes":[{"subj":"26834548-175-183-278867","pred":"source","obj":"TEST0"},{"subj":"26834548-151-159-278868","pred":"source","obj":"TEST0"},{"subj":"26834548-143-151-278869","pred":"source","obj":"TEST0"},{"subj":"26834548-156-164-278870","pred":"source","obj":"TEST0"},{"subj":"26834548-174-182-278871","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"26834548-25179671-278867","span":{"begin":272,"end":276},"obj":"25179671"},{"id":"26834548-24450890-278868","span":{"begin":430,"end":434},"obj":"24450890"},{"id":"26834548-21147995-278869","span":{"begin":794,"end":798},"obj":"21147995"},{"id":"26834548-20980799-278870","span":{"begin":807,"end":811},"obj":"20980799"},{"id":"26834548-24176981-278871","span":{"begin":825,"end":829},"obj":"24176981"}],"attributes":[{"subj":"26834548-25179671-278867","pred":"source","obj":"0_colil"},{"subj":"26834548-24450890-278868","pred":"source","obj":"0_colil"},{"subj":"26834548-21147995-278869","pred":"source","obj":"0_colil"},{"subj":"26834548-20980799-278870","pred":"source","obj":"0_colil"},{"subj":"26834548-24176981-278871","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"26834548-25179671-38218457","span":{"begin":272,"end":276},"obj":"25179671"},{"id":"26834548-24450890-38218458","span":{"begin":430,"end":434},"obj":"24450890"},{"id":"26834548-21147995-38218459","span":{"begin":794,"end":798},"obj":"21147995"},{"id":"26834548-20980799-38218460","span":{"begin":807,"end":811},"obj":"20980799"},{"id":"26834548-24176981-38218461","span":{"begin":825,"end":829},"obj":"24176981"}],"attributes":[{"subj":"26834548-25179671-38218457","pred":"source","obj":"2_test"},{"subj":"26834548-24450890-38218458","pred":"source","obj":"2_test"},{"subj":"26834548-21147995-38218459","pred":"source","obj":"2_test"},{"subj":"26834548-20980799-38218460","pred":"source","obj":"2_test"},{"subj":"26834548-24176981-38218461","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ec93a7","default":true},{"id":"0_colil","color":"#93c1ec"},{"id":"2_test","color":"#dbec93"}]}]}}