PMC:4701709 / 9192-10629 JSONTXT

{"project":"2_test","denotations":[{"id":"28330081-16054514-323","span":{"begin":155,"end":159},"obj":"16054514"},{"id":"28330081-23620851-324","span":{"begin":1269,"end":1273},"obj":"23620851"}],"text":"The antipyretic activities of Z. nummularia root extract were assessed in Brewer’s yeast (Saccharomyces cerevisiae)-induced hyperthermia (Tomazetti et al. 2005). Pyrexia was induced in mice by injection of 10 ml/kg of 15 % suspension of yeast. The normal body temperature of the animals was recorded with a digital clinical thermometer (Hartmann, Germany) using rectum, while the tail was fastened with an adhesive tape. The rectal temperature of each mouse was measured again after 19 h of yeast injection as described above. Mice that developed a minimum increase of 0.5 °C or more temperature were selected for the experiment. These rodents were categorized in group of size 6. A group of mice was fed with saline (10 ml/kg) and used as negative control, whereas other groups was treated either with paracetmol (100 mg/kg through intraperitoneal injection) as standard drug or Z. nummularia root extract at the doses of 50 and 100 mg/kg. After the respective treatment, the rectal temperature of each animal was again recorded at 1 h intervals for following 5 h. The obtained data were used for the calculation of percentage reduction in rectal temperature. Antipyretic activity was defined as the efficacy of test drug to abate the induced-pyrexia (Muhammad et al. 2013).Reduction in temperature%=B-CB-A×100where A is the normal body temperature, B is the temperature after pyrexia induction, C is the temperature after 1, 3 and 5 h."}