PMC:4701709 / 12411-14172 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4701709","sourcedb":"PMC","sourceid":"4701709","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4701709","text":"Effect of extract in open field test\nThe effect of Z. nummularia roots extract at 50 and 100 mg/kg, in phenobarbitone-sleep in mice is shown in Table 1. The extract significantly (p \u003c 0.05) reduced the sleep latency time (time taken for the onset of sleep) and increased the sleep in dose-dependent manner. Chloroform followed by ethyl acetate extract was the most potent fraction in inducing sleep and increasing its duration. The soporific effect elicited by the extract in bromazepam treated group was highly significant (p \u003c 0.001).\nTable 1 The effect of Z. nummularia root fractions in phenobarbitone-induced sleep in mice\nDrug Intraperitoneal dose Onset of sleep (min) Duration of sleep (min)\nNormal saline 10 ml/kg + phenobarbitone 23.27 ± 1.09 7.56 ± 2.45\nCrude extract 50 mg/kg + phenobarbitone 18.10 ± 2.70 15.40 ± 1.75\n100 mg/kg + phenobarbitone 14.33 ± 1.08* 23.88 ± 2.75*\nHexane 50 mg/kg + phenobarbitone 19.66 ± 1.12 9.45 ± 0.67\n100 mg/kg + phenobarbitone 19.00 ± 1.05 9.60 ± 1.06\nChloroform 50 mg/kg + phenobarbitone 15.33 ± 1.21* 22.33 ± 1.12*\n100 mg/kg + phenobarbitone 10.56 ± 0.99** 27.05 ± 1.35**\nEthyl acetate 50 mg/kg + phenobarbitone 18.44 ± 1.12* 20.12 ± 1.45*\n100 mg/kg + phenobarbitone 12.57 ± 1.49* 23.67 ± 1.56*\nAqueous 50 mg/kg + phenobarbitone 17.44 ± 1.06 17.04 ± 0.99*\n100 mg/kg + phenobarbitone 13.03 ± 0.89* 23.55 ± 1.77*\nBromazepam 5 mg/kg + phenobarbitone 3.25 ± 1.10*** 61.45 ± 1.10***\n* Data shows the onset and duration of sleep (in min) in mice pretreated with normal saline (10 ml/kg), extract/fractions (50 and 100 mg/kg) or bromazepam (5 mg/kg) and then all groups were treated with phenobarbitone (35 mg/kg). Data presented as mean ± S.E.M, (n = 6). * p \u003c 0.05, ** p \u003c 0.01, *** p \u003c 0.001, all with respect to control","divisions":[{"label":"title","span":{"begin":0,"end":36}},{"label":"label","span":{"begin":537,"end":544}},{"label":"caption","span":{"begin":545,"end":627}},{"label":"p","span":{"begin":545,"end":627}},{"label":"table","span":{"begin":628,"end":1422}},{"label":"tr","span":{"begin":628,"end":698}},{"label":"th","span":{"begin":628,"end":632}},{"label":"th","span":{"begin":633,"end":653}},{"label":"th","span":{"begin":654,"end":674}},{"label":"th","span":{"begin":675,"end":698}},{"label":"tr","span":{"begin":699,"end":763}},{"label":"td","span":{"begin":699,"end":712}},{"label":"td","span":{"begin":713,"end":738}},{"label":"td","span":{"begin":739,"end":751}},{"label":"td","span":{"begin":752,"end":763}},{"label":"tr","span":{"begin":764,"end":829}},{"label":"td","span":{"begin":764,"end":777}},{"label":"td","span":{"begin":778,"end":803}},{"label":"td","span":{"begin":804,"end":816}},{"label":"td","span":{"begin":817,"end":829}},{"label":"tr","span":{"begin":830,"end":884}},{"label":"td","span":{"begin":830,"end":856}},{"label":"td","span":{"begin":857,"end":870}},{"label":"td","span":{"begin":871,"end":884}},{"label":"tr","span":{"begin":885,"end":942}},{"label":"td","span":{"begin":885,"end":891}},{"label":"td","span":{"begin":892,"end":917}},{"label":"td","span":{"begin":918,"end":930}},{"label":"td","span":{"begin":931,"end":942}},{"label":"tr","span":{"begin":943,"end":994}},{"label":"td","span":{"begin":943,"end":969}},{"label":"td","span":{"begin":970,"end":982}},{"label":"td","span":{"begin":983,"end":994}},{"label":"tr","span":{"begin":995,"end":1059}},{"label":"td","span":{"begin":995,"end":1005}},{"label":"td","span":{"begin":1006,"end":1031}},{"label":"td","span":{"begin":1032,"end":1045}},{"label":"td","span":{"begin":1046,"end":1059}},{"label":"tr","span":{"begin":1060,"end":1116}},{"label":"td","span":{"begin":1060,"end":1086}},{"label":"td","span":{"begin":1087,"end":1101}},{"label":"td","span":{"begin":1102,"end":1116}},{"label":"tr","span":{"begin":1117,"end":1184}},{"label":"td","span":{"begin":1117,"end":1130}},{"label":"td","span":{"begin":1131,"end":1156}},{"label":"td","span":{"begin":1157,"end":1170}},{"label":"td","span":{"begin":1171,"end":1184}},{"label":"tr","span":{"begin":1185,"end":1239}},{"label":"td","span":{"begin":1185,"end":1211}},{"label":"td","span":{"begin":1212,"end":1225}},{"label":"td","span":{"begin":1226,"end":1239}},{"label":"tr","span":{"begin":1240,"end":1300}},{"label":"td","span":{"begin":1240,"end":1247}},{"label":"td","span":{"begin":1248,"end":1273}},{"label":"td","span":{"begin":1274,"end":1286}},{"label":"td","span":{"begin":1287,"end":1300}},{"label":"tr","span":{"begin":1301,"end":1355}},{"label":"td","span":{"begin":1301,"end":1327}},{"label":"td","span":{"begin":1328,"end":1341}},{"label":"td","span":{"begin":1342,"end":1355}},{"label":"tr","span":{"begin":1356,"end":1422}},{"label":"td","span":{"begin":1356,"end":1366}},{"label":"td","span":{"begin":1367,"end":1391}},{"label":"td","span":{"begin":1392,"end":1406}},{"label":"td","span":{"begin":1407,"end":1422}}],"tracks":[]}