PMC:4693303 / 25741-26781 JSONTXT

{"project":"TEST0","denotations":[{"id":"26752867-237-243-1465730","span":{"begin":504,"end":506},"obj":"[\"26248676\"]"}],"text":"Very recently, trials of new Ebola vaccine vesicular stomatitis virus (VSV)-EBOV (an attenuated livestock vaccine developed by the Public Health Agency of Canada and licensed to NewLink Genetics and Merck) have been shown to carry sufficient promise that WHO felt it was indicated to immediately vaccinate all individuals at risk of being in close contact with an infected person.[61] Henao-Restrepo et al. recently completed an open-label, cluster-randomized ring phase III vaccination trial in Guinea.[62] This trial was called “Ebola, çasuffit” (in French, “Ebola, that's enough”), and was designed based on the 1970s smallpox elimination programs. When a case was identified, all known close contacts were vaccinated (e.g., the “ring” of contacts). The authors reported an interim analysis of a recombinant, replication-competent VSV-based vaccine expressing the surface glycoprotein of Zaire Ebolavirus. The vaccine was tested on 90 clusters of 7651 people between April 1, 2015 and July 20, 2015. Two distinct sub-groups were studied:"}

{"project":"2_test","denotations":[{"id":"26752867-26248676-60482796","span":{"begin":504,"end":506},"obj":"26248676"}],"text":"Very recently, trials of new Ebola vaccine vesicular stomatitis virus (VSV)-EBOV (an attenuated livestock vaccine developed by the Public Health Agency of Canada and licensed to NewLink Genetics and Merck) have been shown to carry sufficient promise that WHO felt it was indicated to immediately vaccinate all individuals at risk of being in close contact with an infected person.[61] Henao-Restrepo et al. recently completed an open-label, cluster-randomized ring phase III vaccination trial in Guinea.[62] This trial was called “Ebola, çasuffit” (in French, “Ebola, that's enough”), and was designed based on the 1970s smallpox elimination programs. When a case was identified, all known close contacts were vaccinated (e.g., the “ring” of contacts). The authors reported an interim analysis of a recombinant, replication-competent VSV-based vaccine expressing the surface glycoprotein of Zaire Ebolavirus. The vaccine was tested on 90 clusters of 7651 people between April 1, 2015 and July 20, 2015. Two distinct sub-groups were studied:"}