PMC:4666274 / 7085-8422 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4666274","sourcedb":"PMC","sourceid":"4666274","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4666274","text":"Qualitative magnetic resonance imaging evaluation\nAll MRI analysis was performed by observers blinded to the subject clinical details, including patient versus control status. The coronal T1w and STIR orbital images were systematically reviewed by two experienced neuroradiologists (I.D. and T.Y.). The individual characteristics of all 12 EOMs were reviewed sequentially in all subjects and the consensus opinion was recorded. A scoring system was applied to capture the following qualitative features: degree of atrophy (normal = 0, mild = 1, marked = 2); STIR hyperintensity (normal = 0, hyperintense = 1); and presence or absence of T1w hyperintensity foci with anatomically coincident STIR hypointensity (presumed to represent fatty infiltration), taking account of the intra-EOM pattern: the intrinsic foci were observed to either be of approximately equal diameter in all dimensions in the coronal plane, termed 'dots', or elongated in one dimension (invariably in-line with the longest dimension of the extra-ocular muscle in the coronal section), termed 'streaks’. Where both dots and streaks were observed in different sections through a single EOM, the convention adopted was to record the muscle as demonstrating an intrinsic 'streak' signal. The qualitative scores were tabulated for both healthy controls and CPEO patients.","divisions":[{"label":"title","span":{"begin":0,"end":49}}],"tracks":[]}