PMC:4652343 / 22792-24782 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4652343","sourcedb":"PMC","sourceid":"4652343","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4652343","text":"My career in science has provided incredible opportunities to travel and meet scientists with different perspectives from around the world. Such interactions are critical to the development of a scientist, and my mentors and colleagues have been extraordinarily generous in sharing their thoughts and ideas. A cornerstone of the perspectives gained throughout my career was the experience that each success evolved out of failure(s). A second important perspective came from the approach of forming and working as part of multidisciplinary research teams with diverse talents needed to solve each problem, particularly operational problems. Physiologists, biochemists, biostatisticians, clinicians, veterinarians, engineers, electronics technicians, and computer programmers could all be found on our teams. My experience of studying the entirety of integrative systemic physiology in humans over the span of 45 years in government and academic laboratories provided me with the unique opportunity to explore how normal physiology of blood volume, circulation and blood pressure regulation in men and women of varying age and fitness levels responds and adapts to extreme conditions. I was able to take unique observations, data and novel technologies from apparently diverse sources or fields, and propose integrated hypotheses or schemes to predict how the body might react to a variety of challenges through some common pathway. Where necessary, I was able to study abnormal physiology that exists in extreme clinical conditions such as patients with heart transplants, para- and quadriplegia, chronic orthostatic hypotension, Dengue hemorrhagic fever, trauma with severe hemorrhage, or those undergoing renal dialysis or childbirth. This thorough and multifaceted approach has inevitably allowed me the most gratifying perspective of learning how to translate experimental basic physiology to operational and clinical solutions that can be applied to advance the well-being of humanity.","tracks":[]}