PMC:4635215 / 7019-8062
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4635215","sourcedb":"PMC","sourceid":"4635215","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4635215","text":"Signals from the nucleus can lead to phosphorylation of Golgi proteins and subsequent Golgi disassembly. For example, GOLPH3 is an oncogene that is upregulated in a number of cancers. It is a peripheral Golgi protein that binds phosphoinositol-4-phosphate at the trans-Golgi as well as the myosin Myo18A (Dippold et al., 2009). Normal Golgi ribbon structure is maintained in part by interaction of the Myo18A-GOLPH3 complex with actin, which keeps the ribbon extended. DNA damage results in Golgi fragmentation, which was shown to occur through phosphorylation of GOLPH3 by DNA-dependent protein kinase (DNA-PK). Phosphorylated GOLPH3 interacts more strongly with Myo18A and thus leads to Golgi dispersal (Farber-Katz et al., 2014). Although this dispersal leads to a reduction in cargo traffic through the Golgi, it is not yet clear how this connects to DNA damage or cell survival. Since DNA-PK can activate caspase-2 (Shi et al., 2009), it will be important to determine if caspase-2 cleavage of Golgi proteins contributes to this response.","tracks":[{"project":"TEST0","denotations":[{"id":"26594142-137-145-125961","span":{"begin":321,"end":325},"obj":"[\"19837035\"]"},{"id":"26594142-113-121-125962","span":{"begin":726,"end":730},"obj":"[\"24485452\"]"},{"id":"26594142-49-57-125963","span":{"begin":933,"end":937},"obj":"[\"19203584\"]"}],"attributes":[{"subj":"26594142-137-145-125961","pred":"source","obj":"TEST0"},{"subj":"26594142-113-121-125962","pred":"source","obj":"TEST0"},{"subj":"26594142-49-57-125963","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"26594142-19837035-125961","span":{"begin":321,"end":325},"obj":"19837035"},{"id":"26594142-24485452-125962","span":{"begin":726,"end":730},"obj":"24485452"},{"id":"26594142-19203584-125963","span":{"begin":933,"end":937},"obj":"19203584"}],"attributes":[{"subj":"26594142-19837035-125961","pred":"source","obj":"0_colil"},{"subj":"26594142-24485452-125962","pred":"source","obj":"0_colil"},{"subj":"26594142-19203584-125963","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"26594142-19837035-38084433","span":{"begin":321,"end":325},"obj":"19837035"},{"id":"26594142-24485452-38084434","span":{"begin":726,"end":730},"obj":"24485452"},{"id":"26594142-19203584-38084435","span":{"begin":933,"end":937},"obj":"19203584"}],"attributes":[{"subj":"26594142-19837035-38084433","pred":"source","obj":"2_test"},{"subj":"26594142-24485452-38084434","pred":"source","obj":"2_test"},{"subj":"26594142-19203584-38084435","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#a493ec","default":true},{"id":"0_colil","color":"#9bec93"},{"id":"2_test","color":"#ec93b5"}]}]}}