PMC:4635215 / 6014-6984 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4635215","sourcedb":"PMC","sourceid":"4635215","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4635215","text":"Another stress that acts at the Golgi complex is inhibition of O-glycosylation. It was shown that treatment of fibroblasts with benzyl 2-acetamido-2-deoxy-a-d-galactopyranoside (GalNAc-bn) to inhibit this post-translational modification induced upregulation of HSP47, an ER chaperone (Miyata et al., 2013). HSP47 apparently protects cells from Golgi fragmentation and death when O-glycosylation is blocked because knock-down of HSP47 in GalNAc-bn treated cells led to Golgi vacuolization and eventual apoptosis. Interestingly, caspase-2 appears to be activated here as well. The mechanism by which HSP47 leads to protection is unknown, but it has been reported to be a collagen-specific chaperone (Mala and Rose, 2010). HSP47 may regulate the level of this abundant secretory protein that enters the Golgi, whereas in its absence collagen might accumulate in the Golgi when it cannot be O-glycosylated, resulting in Golgi structural perturbations and eventual apoptosis.","tracks":[{"project":"TEST0","denotations":[{"id":"26594142-220-228-125959","span":{"begin":300,"end":304},"obj":"[\"23922785\"]"},{"id":"26594142-138-146-125960","span":{"begin":713,"end":717},"obj":"[\"20888348\"]"}],"attributes":[{"subj":"26594142-220-228-125959","pred":"source","obj":"TEST0"},{"subj":"26594142-138-146-125960","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"26594142-23922785-125959","span":{"begin":300,"end":304},"obj":"23922785"},{"id":"26594142-20888348-125960","span":{"begin":713,"end":717},"obj":"20888348"}],"attributes":[{"subj":"26594142-23922785-125959","pred":"source","obj":"0_colil"},{"subj":"26594142-20888348-125960","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"26594142-23922785-38084431","span":{"begin":300,"end":304},"obj":"23922785"},{"id":"26594142-20888348-38084432","span":{"begin":713,"end":717},"obj":"20888348"}],"attributes":[{"subj":"26594142-23922785-38084431","pred":"source","obj":"2_test"},{"subj":"26594142-20888348-38084432","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#d5ec93","default":true},{"id":"0_colil","color":"#e993ec"},{"id":"2_test","color":"#93eccf"}]}]}}