PMC:4635215 / 12675-13719 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4635215","sourcedb":"PMC","sourceid":"4635215","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4635215","text":"Golgi fragmentation has been observed for decades in neurons from patients and in animal models of neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer's disease, Creutzfeld-Jacob disease and spinocerebellar ataxia type 2 (Gonatas et al., 2006). But does the fragmentation induce neuron dysfunction or is it simply a downsteam effect? Most evidence suggests that Golgi disruption occurs prior to cell death or disease phenotypes. In cortical neurons undergoing excitotoxicity or oxidative or nitrosyl stress, Golgi fragmentation precedes cell death, and both fragmentation and death could be blocked when Golgi structure was rescued with expression of a C-terminal GRASP65 fragment (Nakagomi et al., 2008). The C-terminal GRASP65 fragment allows formation of GRASP oligomers but cannot be phosphorylated, which is required for disassembly. Golgi fragmentation usually results in decreased or blocked trafficking to the cell surface. This would be expected to impair cellular function and could contribute to apoptosis.","tracks":[{"project":"TEST0","denotations":[{"id":"26594142-227-235-125977","span":{"begin":265,"end":269},"obj":"[\"16545397\"]"},{"id":"26594142-224-232-125978","span":{"begin":726,"end":730},"obj":"[\"17964175\"]"}],"attributes":[{"subj":"26594142-227-235-125977","pred":"source","obj":"TEST0"},{"subj":"26594142-224-232-125978","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"26594142-16545397-125977","span":{"begin":265,"end":269},"obj":"16545397"},{"id":"26594142-17964175-125978","span":{"begin":726,"end":730},"obj":"17964175"}],"attributes":[{"subj":"26594142-16545397-125977","pred":"source","obj":"0_colil"},{"subj":"26594142-17964175-125978","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"26594142-16545397-38084449","span":{"begin":265,"end":269},"obj":"16545397"},{"id":"26594142-17964175-38084450","span":{"begin":726,"end":730},"obj":"17964175"}],"attributes":[{"subj":"26594142-16545397-38084449","pred":"source","obj":"2_test"},{"subj":"26594142-17964175-38084450","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#93deec","default":true},{"id":"0_colil","color":"#ece093"},{"id":"2_test","color":"#c693ec"}]}]}}