PMC:4635215 / 11733-12626 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4635215","sourcedb":"PMC","sourceid":"4635215","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4635215","text":"Another signaling pathway recently identified that may impact Golgi stress due to pathogen infection involves ADP-ribosylation factor (ARF)-4 and the transcription factor CREB3 (Reiling et al., 2013). Originally identified through a screen for brefeldin A-resistance, ARF4 levels increase when cells are exposed to Golgi disrupting treatments, and this requires the CREB3 transcription factor. Cells depleted of ARF4 or CREB3 contain increased levels of ARF1, 3, and 5, and are more resistant to infection with Chlamydia and Shigella. These results suggest that ARF4 may be induced by infection with these pathogenic bacteria to promote Golgi structural rearrangements required for efficient growth. How Golgi perturbation activates CREB3 is unknown. An earlier finding of caspase-2 involvement in infection with pathogenic bacteria is also intriguing in this light (Jesenberger et al., 2000).","tracks":[{"project":"TEST0","denotations":[{"id":"26594142-194-202-125975","span":{"begin":194,"end":198},"obj":"[\"24185178\"]"},{"id":"26594142-136-144-125976","span":{"begin":887,"end":891},"obj":"[\"11015444\"]"}],"attributes":[{"subj":"26594142-194-202-125975","pred":"source","obj":"TEST0"},{"subj":"26594142-136-144-125976","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"26594142-24185178-125975","span":{"begin":194,"end":198},"obj":"24185178"},{"id":"26594142-11015444-125976","span":{"begin":887,"end":891},"obj":"11015444"}],"attributes":[{"subj":"26594142-24185178-125975","pred":"source","obj":"0_colil"},{"subj":"26594142-11015444-125976","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"26594142-24185178-38084447","span":{"begin":194,"end":198},"obj":"24185178"},{"id":"26594142-11015444-38084448","span":{"begin":887,"end":891},"obj":"11015444"}],"attributes":[{"subj":"26594142-24185178-38084447","pred":"source","obj":"2_test"},{"subj":"26594142-11015444-38084448","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#93ecea","default":true},{"id":"0_colil","color":"#ecd093"},{"id":"2_test","color":"#b693ec"}]}]}}