PMC:4631427 / 20695-21725 JSONTXT

{"project":"TEST0","denotations":[{"id":"26604803-196-202-1382685","span":{"begin":196,"end":198},"obj":"[\"16546624\"]"},{"id":"26604803-232-238-1382686","span":{"begin":495,"end":497},"obj":"[\"20819321\"]"},{"id":"26604803-235-241-1382687","span":{"begin":498,"end":500},"obj":"[\"20621344\"]"},{"id":"26604803-235-241-1382688","span":{"begin":501,"end":503},"obj":"[\"14767453\"]"},{"id":"26604803-211-217-1382689","span":{"begin":1028,"end":1030},"obj":"[\"23507835\"]"}],"text":"The USA, European, and international guidelines (World Allergy Organization [WAO]) all recommend epinephrine as the drug of choice for all causes of anaphylaxis including food-induced anaphylaxis.65 The appropriate dose should be promptly administered upon onset of symptoms. Failure to receive epinephrine in a timely manner is a risk factor for fatality due to anaphylaxis, and studies have demonstrated that epinephrine is administered in only 25%–44% of patients with anaphylactic reactions.55,56,66 Additional therapies for anaphylactic reactions include supplemental oxygen and volume repletion for hypotension when appropriate. Symptom-specific adjunctive therapies may also be considered. These would include bronchodilators for wheezing and H1-antihistamines for pruritus, cutaneous symptoms, or rhinorrhea. Systemic corticosteroids in the acute management of anaphylaxis have been shown to be of questionable value, though they are routinely used as a second-line agent for possible prevention of late-phase reactions.67"}

{"project":"2_test","denotations":[{"id":"26604803-16546624-55579380","span":{"begin":196,"end":198},"obj":"16546624"},{"id":"26604803-20819321-55579381","span":{"begin":495,"end":497},"obj":"20819321"},{"id":"26604803-20621344-55579382","span":{"begin":498,"end":500},"obj":"20621344"},{"id":"26604803-14767453-55579383","span":{"begin":501,"end":503},"obj":"14767453"},{"id":"26604803-23507835-55579384","span":{"begin":1028,"end":1030},"obj":"23507835"}],"text":"The USA, European, and international guidelines (World Allergy Organization [WAO]) all recommend epinephrine as the drug of choice for all causes of anaphylaxis including food-induced anaphylaxis.65 The appropriate dose should be promptly administered upon onset of symptoms. Failure to receive epinephrine in a timely manner is a risk factor for fatality due to anaphylaxis, and studies have demonstrated that epinephrine is administered in only 25%–44% of patients with anaphylactic reactions.55,56,66 Additional therapies for anaphylactic reactions include supplemental oxygen and volume repletion for hypotension when appropriate. Symptom-specific adjunctive therapies may also be considered. These would include bronchodilators for wheezing and H1-antihistamines for pruritus, cutaneous symptoms, or rhinorrhea. Systemic corticosteroids in the acute management of anaphylaxis have been shown to be of questionable value, though they are routinely used as a second-line agent for possible prevention of late-phase reactions.67"}