PMC:4630263 / 14489-17922
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4630263","sourcedb":"PMC","sourceid":"4630263","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4630263","text":"oVEMP abnormalities\nEight patients in the migraine group (7, 18.4 % unilateral; 1, 2.6 % bilateral) demonstrated absent oVEMP responses, while responses could not be obtained for three patients in the TTH group (2, 6.7 % unilateral; 1, 3.3 % bilateral) and five patients in the control group (3, 6.0 % unilateral; 2, 4.0 % bilateral). A low response rate was observed in migraineurs, but no statistical difference was detected in the response rate of oVEMP among groups (Table 2). In oVEMP, the migraine group had mean latencies of bilateral n1 and left p1 significantly longer than the other groups (p \u003c 0.05). Mean amplitudes of n1-p1 were lower than in the other groups, but the difference did not reach statistical significance (Table 3). No significant difference was observed in the AR amplitude or interaural latency differences of oVEMP. Illustrated examples of oVEMP tracings in controls and patients with migraine are shown in Fig. 1. Box plots of statistically significant oVEMP parameters are shown in Fig. 2.\nTable 2 VEMP response rates in headache patients and healthy controls\nTTH (n = 30) Migraine (n = 38) Controls (n = 50)\noVEMP\nBilateral response, n (%) 27 (90.0 %) 30 (78.9 %) 45 (90.0 %)\nUnilateral response, n (%) 2 (6.7 %) 7 (18.4 %) 3 (6.0 %)\nNo response, n (%) 1 (3.3 %) 1 (2.6 %) 2 (4.0 %)\ncVEMP\nBilateral response, n (%) 23 (76.7 %) 34 (89.5 %) 46 (92.0 %)\nUnilateral response, n (%) 7 (23.3 %) 4 (10.5 %) 3 (6.0 %)\nNo response, n (%) 0 (0 %) 0 (0 %) 1 (2.0 %)\nTTH tension-type headache, oVEMP ocular vestibular evoked myogenic potential, cVEMP cervical vestibular evoked myogenic potential\nTable 3 oVEMP results of headache patients and healthy controls\nParameters TTH Migraine Controls\nLeft side\nlatency n1 (ms) 11.29 ± 0.78** 12.34 ± 1.43*,** 11.29 ± 0.73*\nlatency p1 (ms) 16.09 ± 0.83 17.05 ± 1.95* 16.11 ± 0.82*\nn1-p1 interpeak latency (ms) 4.79 ± 0.87 4.75 ± 1.22 4.82 ± 0.92\nn1-p1 amplitude 11.64 ± 6.73 8.00 ± 5.21+ 11.66 ± 9.14\nRight side\nlatency n1 (ms) 11.42 ± 0.86** 12.41 ± 1.41*,** 11.58 ± 0.90*\nlatency p1 (ms) 16.41 ± 0.89 16.99 ± 2.02 16.20 ± 1.04\nn1-p1 interpeak latency (ms) 4.99 ± 1.02 4.58 ± 1.24 4.62 ± 1.00\nn1-p1 amplitude 11.29 ± 6.77 7.51 ± 4.47+ 11.76 ± 10.79\nInterside difference\ninteraural latency diff., n1 0.64 ± 0.86 0.91 ± 0.97 0.74 ± 0.72\ninteraural latency diff., p1 0.64 ± 0.55 0.84 ± 0.95 0.78 ± 0.62\namp. asymmetry ratio, n1 0.23 ± 0.17 0.28 ± 0.17 0.23 ± 0.16\namp. asymmetry ratio, n1 0.22 ± 0.19 0.28 ± 0.21 0.24 ± 0.15\n*p \u003c 0.05, statistically significant between patients with migraine and controls; **p \u003c 0.05, statistically significant between patients with migraine and patients with TTH; values are expressed as the means ± standard deviation\nTTH tension-type headache, oVEMP ocular vestibular-evoked myogenic potential, amp amplitude\nFig. 1 oVEMP and rectified cVEMP responses in normal subjects (a-1, b-1, respectively) and migraine patients (a-2, b-2, respectively). oVEMP: ocular vestibular evoked myogenic potential; cVEMP: cervical vestibular evoked myogenic potential\nFig. 2 Box plots of latency of oVEMP. Latencies of a left n1, b left p1, and c right n1. Horizontal dashed lines indicate the grand average. *p \u003c 0.05, statistically significant difference between migraine patients and healthy controls; † p \u003c 0.05, statistically significant difference between migraine patients and patients with TTH; oVEMP: ocular vestibular evoked myogenic 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