PMC:4630240 / 34163-35385
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4630240","sourcedb":"PMC","sourceid":"4630240","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4630240","text":"As other neurophysiological studies, ours has some methodological shortcomings. For instance, the investigators were blinded during off-line analyses of VEP data, as applied in previous studies by independent groups [15, 73], but not to diagnosis during the recording session, although this is probably only a minor risk for bias. As a matter of fact, in a clinical setting it is quasi impossible to totally blind a neurophysiological study. Even in VEP studies that found no abnormalities in migraineurs and were claimed to be blinded to diagnosis [12, 74, 75], blinding was not perfect for various reasons according to the reported methodology: 1) the neurophysiologist knew which set of responses belonged to each of the 6 blocks of averagings [74], which allows a selection bias in favour of low amplitude responses and thus normal habituation [76]; 2) the neurophysiologist was not blinded to check size [74], to which VEP amplitudes are quite sensitive [77]; 3) after each recording, the investigators guessed the correct diagnosis in more than half of subjects [12]; 4) although the investigators were blinded to diagnosis during the first examination, they were not during the 3 subsequent recording sessions [75].","tracks":[{"project":"TEST0","denotations":[{"id":"26527348-137-143-1500505","span":{"begin":217,"end":219},"obj":"[\"23565983\"]"},{"id":"26527348-141-147-1500506","span":{"begin":221,"end":223},"obj":"[\"24332446\"]"},{"id":"26527348-108-114-1500507","span":{"begin":550,"end":552},"obj":"[\"23298223\"]"},{"id":"26527348-236-242-1500508","span":{"begin":960,"end":962},"obj":"[\"5729913\"]"},{"id":"26527348-233-239-1500509","span":{"begin":1069,"end":1071},"obj":"[\"23298223\"]"}],"attributes":[{"subj":"26527348-137-143-1500505","pred":"source","obj":"TEST0"},{"subj":"26527348-141-147-1500506","pred":"source","obj":"TEST0"},{"subj":"26527348-108-114-1500507","pred":"source","obj":"TEST0"},{"subj":"26527348-236-242-1500508","pred":"source","obj":"TEST0"},{"subj":"26527348-233-239-1500509","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"26527348-23565983-60555244","span":{"begin":217,"end":219},"obj":"23565983"},{"id":"26527348-24332446-60555245","span":{"begin":221,"end":223},"obj":"24332446"},{"id":"26527348-23298223-60555246","span":{"begin":550,"end":552},"obj":"23298223"},{"id":"26527348-5729913-60555247","span":{"begin":960,"end":962},"obj":"5729913"},{"id":"26527348-23298223-60555248","span":{"begin":1069,"end":1071},"obj":"23298223"}],"attributes":[{"subj":"26527348-23565983-60555244","pred":"source","obj":"2_test"},{"subj":"26527348-24332446-60555245","pred":"source","obj":"2_test"},{"subj":"26527348-23298223-60555246","pred":"source","obj":"2_test"},{"subj":"26527348-5729913-60555247","pred":"source","obj":"2_test"},{"subj":"26527348-23298223-60555248","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ec9b93","default":true},{"id":"2_test","color":"#93a5ec"}]}]}}