PMC:4630240 / 28185-29335 JSONTXT

{"project":"TEST0","denotations":[{"id":"26527348-154-160-1500481","span":{"begin":154,"end":156},"obj":"[\"16467392\"]"},{"id":"26527348-158-164-1500482","span":{"begin":158,"end":160},"obj":"[\"18971930\"]"},{"id":"26527348-144-150-1500483","span":{"begin":307,"end":309},"obj":"[\"16033381\"]"},{"id":"26527348-148-154-1500484","span":{"begin":311,"end":313},"obj":"[\"21816769\"]"},{"id":"26527348-152-158-1500485","span":{"begin":315,"end":317},"obj":"[\"23980899\"]"},{"id":"26527348-222-228-1500486","span":{"begin":542,"end":544},"obj":"[\"17970989\"]"},{"id":"26527348-186-192-1500487","span":{"begin":733,"end":735},"obj":"[\"1603349\"]"},{"id":"26527348-190-196-1500488","span":{"begin":737,"end":739},"obj":"[\"8857754\"]"},{"id":"26527348-234-240-1500489","span":{"begin":1142,"end":1144},"obj":"[\"17986271\"]"},{"id":"26527348-235-241-1500490","span":{"begin":1146,"end":1148},"obj":"[\"8761712\"]"}],"text":"The neurovascular tone is modulated by local factors such as oxygen availability or lactate concentrations, and by subcortical monoaminergic projections [52, 53]. During continuous visual stimulation neurovascular coupling is impaired in migraine patients between attacks, especially in migraine with aura [34, 54, 55]. There is also circumstantial evidence from biochemical and functional neuroimaging studies that monoaminergic, in particular serotonergic, transmission from the brainstem to the thalamus and cortex is altered in migraine [56]. Finally, convergent data from various laboratories have shown that the mitochondrial energy reserve and ATP levels are significantly reduced in the brain of migraineurs between attacks [27, 28]. Based on these biochemical and functional data, we have proposed that migraine is characterized interictally by a cycling dysregulation of the serotoninergic control of thalamo-cortical activity that causes varying degrees of cortical hyperresponsivity and thus increased energy demands, which, under the influence of triggering or aggravating factors, may disrupt homeostasis and lead to an attack [14, 57]."}

{"project":"2_test","denotations":[{"id":"26527348-16467392-60555220","span":{"begin":154,"end":156},"obj":"16467392"},{"id":"26527348-18971930-60555221","span":{"begin":158,"end":160},"obj":"18971930"},{"id":"26527348-16033381-60555222","span":{"begin":307,"end":309},"obj":"16033381"},{"id":"26527348-21816769-60555223","span":{"begin":311,"end":313},"obj":"21816769"},{"id":"26527348-23980899-60555224","span":{"begin":315,"end":317},"obj":"23980899"},{"id":"26527348-17970989-60555225","span":{"begin":542,"end":544},"obj":"17970989"},{"id":"26527348-1603349-60555226","span":{"begin":733,"end":735},"obj":"1603349"},{"id":"26527348-8857754-60555227","span":{"begin":737,"end":739},"obj":"8857754"},{"id":"26527348-17986271-60555228","span":{"begin":1142,"end":1144},"obj":"17986271"},{"id":"26527348-8761712-60555229","span":{"begin":1146,"end":1148},"obj":"8761712"}],"text":"The neurovascular tone is modulated by local factors such as oxygen availability or lactate concentrations, and by subcortical monoaminergic projections [52, 53]. During continuous visual stimulation neurovascular coupling is impaired in migraine patients between attacks, especially in migraine with aura [34, 54, 55]. There is also circumstantial evidence from biochemical and functional neuroimaging studies that monoaminergic, in particular serotonergic, transmission from the brainstem to the thalamus and cortex is altered in migraine [56]. Finally, convergent data from various laboratories have shown that the mitochondrial energy reserve and ATP levels are significantly reduced in the brain of migraineurs between attacks [27, 28]. Based on these biochemical and functional data, we have proposed that migraine is characterized interictally by a cycling dysregulation of the serotoninergic control of thalamo-cortical activity that causes varying degrees of cortical hyperresponsivity and thus increased energy demands, which, under the influence of triggering or aggravating factors, may disrupt homeostasis and lead to an attack [14, 57]."}