PMC:4630240 / 2225-2939 JSONTXT

{"project":"TEST0","denotations":[{"id":"26527348-229-234-1500440","span":{"begin":299,"end":300},"obj":"[\"11595007\"]"},{"id":"26527348-232-237-1500441","span":{"begin":302,"end":303},"obj":"[\"24042483\"]"},{"id":"26527348-94-99-1500442","span":{"begin":400,"end":401},"obj":"[\"2285266\", \"10328249\", \"11287655\"]"},{"id":"26527348-125-130-1500443","span":{"begin":431,"end":432},"obj":"[\"11706963\"]"},{"id":"26527348-136-142-1500444","span":{"begin":579,"end":581},"obj":"[\"20592202\"]"},{"id":"26527348-140-146-1500445","span":{"begin":583,"end":585},"obj":"[\"21416489\"]"}],"text":"The most likely cause of the migraine aura, Leão’s cortical spreading depression (CSD), consists of a brief neuronal depolarisation followed by a long-lasting wave of neuronal depression that often spreads postero-anteriorly in the occipital cortex and can reach the parietal and/or temporal lobes [4, 5]. Indirect evidence for CSD occurrence in migraine patients stems from functional neuroimaging [6–8] and electrophysiological [9] studies. Although in animal models CSD is able to activate peripheral and central trigeminovascular neurons that underlie the migraine headache [10, 11], knowledge is lacking on the possible relation of CSD to interictal neural alterations that may predispose to migraine attacks."}

{"project":"2_test","denotations":[{"id":"26527348-11595007-60555179","span":{"begin":299,"end":300},"obj":"11595007"},{"id":"26527348-24042483-60555180","span":{"begin":302,"end":303},"obj":"24042483"},{"id":"26527348-2285266-60555181","span":{"begin":400,"end":401},"obj":"2285266"},{"id":"26527348-10328249-60555181","span":{"begin":400,"end":401},"obj":"10328249"},{"id":"26527348-11287655-60555181","span":{"begin":400,"end":401},"obj":"11287655"},{"id":"26527348-11706963-60555182","span":{"begin":431,"end":432},"obj":"11706963"},{"id":"26527348-20592202-60555183","span":{"begin":579,"end":581},"obj":"20592202"},{"id":"26527348-21416489-60555184","span":{"begin":583,"end":585},"obj":"21416489"}],"text":"The most likely cause of the migraine aura, Leão’s cortical spreading depression (CSD), consists of a brief neuronal depolarisation followed by a long-lasting wave of neuronal depression that often spreads postero-anteriorly in the occipital cortex and can reach the parietal and/or temporal lobes [4, 5]. Indirect evidence for CSD occurrence in migraine patients stems from functional neuroimaging [6–8] and electrophysiological [9] studies. Although in animal models CSD is able to activate peripheral and central trigeminovascular neurons that underlie the migraine headache [10, 11], knowledge is lacking on the possible relation of CSD to interictal neural alterations that may predispose to migraine attacks."}