PMC:4627622 / 24476-25429 JSONTXT

{"project":"TEST0","denotations":[{"id":"26512021-119-125-1479112","span":{"begin":305,"end":307},"obj":"[\"26329487\"]"},{"id":"26512021-166-172-1479113","span":{"begin":558,"end":560},"obj":"[\"9209773\"]"},{"id":"26512021-56-62-1479114","span":{"begin":619,"end":621},"obj":"[\"7606344\"]"}],"text":"The addition of the inflammatory substances onto the dura mater raises an interesting question in relation to the vasogenic theory. Does the inflammatory substance lead to vasodilation? IS caused a mild contraction and CFA had no vasomotor effect per se on the in vitro MMA, studied using wire myography [24]. In our model, we could however not observe any changes in the meningeal arteries. Interestingly, Williamson and colleagues showed that in closed cranial window an increase in the MMA diameter of up to 180 % could be seen with the addition of CGRP [40]. However, in open cranial window only 15 % was observed [41], and therefore changes are difficult to detect. The effect of IS and CFA on the MMA will require further analysis, but this is not in the scope of this study. Here we show that in our model of application of IS and CFA we do not see any changes in MMA, we do however see an increased blood flow to this area, particularly for CFA."}

{"project":"2_test","denotations":[{"id":"26512021-26329487-60534754","span":{"begin":305,"end":307},"obj":"26329487"},{"id":"26512021-9209773-60534755","span":{"begin":558,"end":560},"obj":"9209773"},{"id":"26512021-7606344-60534756","span":{"begin":619,"end":621},"obj":"7606344"}],"text":"The addition of the inflammatory substances onto the dura mater raises an interesting question in relation to the vasogenic theory. Does the inflammatory substance lead to vasodilation? IS caused a mild contraction and CFA had no vasomotor effect per se on the in vitro MMA, studied using wire myography [24]. In our model, we could however not observe any changes in the meningeal arteries. Interestingly, Williamson and colleagues showed that in closed cranial window an increase in the MMA diameter of up to 180 % could be seen with the addition of CGRP [40]. However, in open cranial window only 15 % was observed [41], and therefore changes are difficult to detect. The effect of IS and CFA on the MMA will require further analysis, but this is not in the scope of this study. Here we show that in our model of application of IS and CFA we do not see any changes in MMA, we do however see an increased blood flow to this area, particularly for CFA."}