PMC:4627622 / 19834-20738 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4627622","sourcedb":"PMC","sourceid":"4627622","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4627622","text":"Discussion\nThis is the first study designed to quantify and compare the permeability in the TG and the CNS. We present results that show the PS (and hence the permeability) was more than 30 times higher in the TG than in other structures (CNS) analysed, strongly indicating that the TG is indeed outside the BBB. The addition of the inflammatory agents, IS or CFA, did not change the permeability in the CNS structures, despite demonstrating an inflammatory reaction in the TG [24]. This will be discussed below in the relation to the pharmacokinetics/BBB and the TG as a possible target for acute migraine treatment. The dura mater does not have a barrier to EBA (Fig. 2c), since we operated in this area it was not included in the quantification. It is worth noting that it is the part of TG that contains the neurons that are “blue” in the TG and that the pale part is the trigeminal nerves (Fig. 2b).","divisions":[{"label":"title","span":{"begin":0,"end":10}}],"tracks":[{"project":"TEST0","denotations":[{"id":"26512021-165-171-1479097","span":{"begin":478,"end":480},"obj":"[\"26329487\"]"}],"attributes":[{"subj":"26512021-165-171-1479097","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"26512021-26329487-60534739","span":{"begin":478,"end":480},"obj":"26329487"}],"attributes":[{"subj":"26512021-26329487-60534739","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ec93be","default":true},{"id":"2_test","color":"#93d8ec"}]}]}}