PMC:4621299 / 3504-4728
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4621299","sourcedb":"PMC","sourceid":"4621299","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4621299","text":"SNAREs are an essential COG partner. SNAREs catalyze the fusion of the vesicle membrane with the target membrane by the assembly of a quaternary SNARE complex that functions as a zipper to coalesce the opposing lipid bilayers While SNAREs alone have an innate ability to fuse membranes, the SNARE regulatory proteins and tethering complexes are thought to be necessary for physiologically relevant fusion events (Rizo and Südhof, 2012). The COG complex interacts with at least two Golgi SNARE complexes: the cis-Golgi STX5/GOSR1(GS28)/YKT6/BET1L(GS15) complex; and the trans-Golgi STX16/STX6/VTI1a/VAMP4 complex (Shestakova et al., 2007; Laufman et al., 2009, 2013b). Additionally, SNARE complexes that contain Sec22b, GOSR2(GS27), or SNAP29 are evidenced to interact with COG (Kudlyk et al., 2013; Willett et al., 2013a). SNARE partner transitions connect all compartments of the endocytic and secretory pathways. Thus, it is likely that a defect in one trafficking step may have a cascading effect on all other cargo trafficking steps. In this review we will focus on those SNAREs where deficiency was shown to be associated with neuronal abnormalities, i.e., Ykt6, Sec22b, STX5, SNAP29, GS27, GS28, and Vti1a/b (Table 1).","tracks":[{"project":"TEST0","denotations":[{"id":"26578865-232-240-323816","span":{"begin":430,"end":434},"obj":"[\"23057743\"]"},{"id":"26578865-195-203-323817","span":{"begin":632,"end":636},"obj":"[\"18086915\"]"},{"id":"26578865-217-225-323818","span":{"begin":654,"end":658},"obj":"[\"19536132\"]"},{"id":"26578865-125-133-323820","span":{"begin":793,"end":797},"obj":"[\"23057818\"]"}],"attributes":[{"subj":"26578865-232-240-323816","pred":"source","obj":"TEST0"},{"subj":"26578865-195-203-323817","pred":"source","obj":"TEST0"},{"subj":"26578865-217-225-323818","pred":"source","obj":"TEST0"},{"subj":"26578865-125-133-323820","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"26578865-23057743-323816","span":{"begin":430,"end":434},"obj":"23057743"},{"id":"26578865-18086915-323817","span":{"begin":632,"end":636},"obj":"18086915"},{"id":"26578865-19536132-323818","span":{"begin":654,"end":658},"obj":"19536132"},{"id":"26578865-23057818-323820","span":{"begin":793,"end":797},"obj":"23057818"}],"attributes":[{"subj":"26578865-23057743-323816","pred":"source","obj":"0_colil"},{"subj":"26578865-18086915-323817","pred":"source","obj":"0_colil"},{"subj":"26578865-19536132-323818","pred":"source","obj":"0_colil"},{"subj":"26578865-23057818-323820","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"26578865-23057743-38257297","span":{"begin":430,"end":434},"obj":"23057743"},{"id":"26578865-18086915-38257298","span":{"begin":632,"end":636},"obj":"18086915"},{"id":"26578865-19536132-38257299","span":{"begin":654,"end":658},"obj":"19536132"},{"id":"26578865-23057818-38257301","span":{"begin":793,"end":797},"obj":"23057818"}],"attributes":[{"subj":"26578865-23057743-38257297","pred":"source","obj":"2_test"},{"subj":"26578865-18086915-38257298","pred":"source","obj":"2_test"},{"subj":"26578865-19536132-38257299","pred":"source","obj":"2_test"},{"subj":"26578865-23057818-38257301","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ec93c7","default":true},{"id":"0_colil","color":"#93e1ec"},{"id":"2_test","color":"#ecdc93"}]}]}}