PMC:4621299 / 22144-22814 JSONTXT

{"project":"TEST0","denotations":[{"id":"26578865-234-242-323958","span":{"begin":310,"end":314},"obj":"[\"7738040\"]"},{"id":"26578865-123-131-323959","span":{"begin":497,"end":501},"obj":"[\"8576122\"]"},{"id":"26578865-160-168-323960","span":{"begin":664,"end":668},"obj":"[\"14992812\"]"}],"text":"Multiple Rabs are associated with processing of APP. For example, ERGIC and cis-Golgi Rab1b-dependent trafficking could modulate the processing of APP as demonstrated in an in vitro system in which a dominant-negative mutant of Rab1b blocked trafficking of APP and decreased the secretion of Aβ (Dugan et al., 1995). trans-Golgi Rab6A is also implicated in APP trafficking. The dominant negative mutant of Rab6 increased the secretion of soluble APP and decreased Aβ secretion (McConlogue et al., 1996). Rab6 membrane association is dependent upon PS1 based on studies using PS1 knockout fibroblasts, thus implicating PS1 in vesicular trafficking (Scheper et al., 2004)."}

{"project":"0_colil","denotations":[{"id":"26578865-7738040-323958","span":{"begin":310,"end":314},"obj":"7738040"},{"id":"26578865-8576122-323959","span":{"begin":497,"end":501},"obj":"8576122"},{"id":"26578865-14992812-323960","span":{"begin":664,"end":668},"obj":"14992812"}],"text":"Multiple Rabs are associated with processing of APP. For example, ERGIC and cis-Golgi Rab1b-dependent trafficking could modulate the processing of APP as demonstrated in an in vitro system in which a dominant-negative mutant of Rab1b blocked trafficking of APP and decreased the secretion of Aβ (Dugan et al., 1995). trans-Golgi Rab6A is also implicated in APP trafficking. The dominant negative mutant of Rab6 increased the secretion of soluble APP and decreased Aβ secretion (McConlogue et al., 1996). Rab6 membrane association is dependent upon PS1 based on studies using PS1 knockout fibroblasts, thus implicating PS1 in vesicular trafficking (Scheper et al., 2004)."}

{"project":"2_test","denotations":[{"id":"26578865-7738040-38257439","span":{"begin":310,"end":314},"obj":"7738040"},{"id":"26578865-8576122-38257440","span":{"begin":497,"end":501},"obj":"8576122"},{"id":"26578865-14992812-38257441","span":{"begin":664,"end":668},"obj":"14992812"}],"text":"Multiple Rabs are associated with processing of APP. For example, ERGIC and cis-Golgi Rab1b-dependent trafficking could modulate the processing of APP as demonstrated in an in vitro system in which a dominant-negative mutant of Rab1b blocked trafficking of APP and decreased the secretion of Aβ (Dugan et al., 1995). trans-Golgi Rab6A is also implicated in APP trafficking. The dominant negative mutant of Rab6 increased the secretion of soluble APP and decreased Aβ secretion (McConlogue et al., 1996). Rab6 membrane association is dependent upon PS1 based on studies using PS1 knockout fibroblasts, thus implicating PS1 in vesicular trafficking (Scheper et al., 2004)."}