PMC:4621299 / 19918-20742 JSONTXT

{"project":"TEST0","denotations":[{"id":"26578865-118-126-323940","span":{"begin":118,"end":122},"obj":"[\"9199167\"]"},{"id":"26578865-141-149-323941","span":{"begin":141,"end":145},"obj":"[\"9398683\"]"},{"id":"26578865-162-170-323942","span":{"begin":162,"end":166},"obj":"[\"24902738\"]"},{"id":"26578865-141-149-323943","span":{"begin":310,"end":314},"obj":"[\"21262811\"]"},{"id":"26578865-231-239-323944","span":{"begin":694,"end":698},"obj":"[\"24902738\"]"},{"id":"26578865-94-102-323945","span":{"begin":795,"end":799},"obj":"[\"17852734\"]"},{"id":"26578865-117-125-323946","span":{"begin":818,"end":822},"obj":"[\"18406529\"]"}],"text":"Vti1a is a TGN-localized SNARE that functions in vesicle generation and Ca2+ channel trafficking (von Mollard et al., 1997; Lupashin et al., 1997; Walter et al., 2014). A double knockout of Vti1a and Vti1b genes results in progressive neurodegeneration and perinatal lethality in a mouse model (Kunwar et al., 2011). Single knockout of Vti1a or Vti1b does not result in a lethal phenotype indicating overlapping functions of these proteins. The death-after-birth clearly demonstrates that these SNAREs are not required during organismal development, indicating a specialized requirement for Vti1a and Vti1b in neurons leading to neurodegeneration in the double-knockout animals (Walter et al., 2014). Vti1a SNARE partners, STX6 and STX16, are also required for neurite outgrowth (Chua and Tang, 2008; Kabayama et al., 2008)."}

{"project":"0_colil","denotations":[{"id":"26578865-9199167-323940","span":{"begin":118,"end":122},"obj":"9199167"},{"id":"26578865-9398683-323941","span":{"begin":141,"end":145},"obj":"9398683"},{"id":"26578865-24902738-323942","span":{"begin":162,"end":166},"obj":"24902738"},{"id":"26578865-21262811-323943","span":{"begin":310,"end":314},"obj":"21262811"},{"id":"26578865-24902738-323944","span":{"begin":694,"end":698},"obj":"24902738"},{"id":"26578865-17852734-323945","span":{"begin":795,"end":799},"obj":"17852734"},{"id":"26578865-18406529-323946","span":{"begin":818,"end":822},"obj":"18406529"}],"text":"Vti1a is a TGN-localized SNARE that functions in vesicle generation and Ca2+ channel trafficking (von Mollard et al., 1997; Lupashin et al., 1997; Walter et al., 2014). A double knockout of Vti1a and Vti1b genes results in progressive neurodegeneration and perinatal lethality in a mouse model (Kunwar et al., 2011). Single knockout of Vti1a or Vti1b does not result in a lethal phenotype indicating overlapping functions of these proteins. The death-after-birth clearly demonstrates that these SNAREs are not required during organismal development, indicating a specialized requirement for Vti1a and Vti1b in neurons leading to neurodegeneration in the double-knockout animals (Walter et al., 2014). Vti1a SNARE partners, STX6 and STX16, are also required for neurite outgrowth (Chua and Tang, 2008; Kabayama et al., 2008)."}

{"project":"2_test","denotations":[{"id":"26578865-9199167-38257421","span":{"begin":118,"end":122},"obj":"9199167"},{"id":"26578865-9398683-38257422","span":{"begin":141,"end":145},"obj":"9398683"},{"id":"26578865-24902738-38257423","span":{"begin":162,"end":166},"obj":"24902738"},{"id":"26578865-21262811-38257424","span":{"begin":310,"end":314},"obj":"21262811"},{"id":"26578865-24902738-38257425","span":{"begin":694,"end":698},"obj":"24902738"},{"id":"26578865-17852734-38257426","span":{"begin":795,"end":799},"obj":"17852734"},{"id":"26578865-18406529-38257427","span":{"begin":818,"end":822},"obj":"18406529"}],"text":"Vti1a is a TGN-localized SNARE that functions in vesicle generation and Ca2+ channel trafficking (von Mollard et al., 1997; Lupashin et al., 1997; Walter et al., 2014). A double knockout of Vti1a and Vti1b genes results in progressive neurodegeneration and perinatal lethality in a mouse model (Kunwar et al., 2011). Single knockout of Vti1a or Vti1b does not result in a lethal phenotype indicating overlapping functions of these proteins. The death-after-birth clearly demonstrates that these SNAREs are not required during organismal development, indicating a specialized requirement for Vti1a and Vti1b in neurons leading to neurodegeneration in the double-knockout animals (Walter et al., 2014). Vti1a SNARE partners, STX6 and STX16, are also required for neurite outgrowth (Chua and Tang, 2008; Kabayama et al., 2008)."}