PMC:4621299 / 16596-17440 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4621299","sourcedb":"PMC","sourceid":"4621299","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4621299","text":"Although the exact molecular mechanisms connecting Golgi fragmentation and disease mutations is still much under investigation, in vitro models can be used to recapitulate Golgi fragmentation seen in neurodegenerative disorders (Suga et al., 2005a). Fragmentation has been recreated in vitro and can be rescued by regulating levels of SNAREs. A STX5 knockdown is known to induce Golgi fragmentation in HeLa cells and cultured neurons (Suga et al., 2005a; Amessou et al., 2007). On the other hand, in PC12 cells treated with 6-hydroxydopamine or methamphetamine (an established in vitro PD model), a decrease in the level of STX5 rescues Golgi fragmentation (Rendón et al., 2013). This same study also demonstrated that Golgi fragmentation could intensify disease progression by inducing α-synuclein aggregation and the formation of Lewy bodies.","tracks":[{"project":"TEST0","denotations":[{"id":"26578865-128-136-323924","span":{"begin":471,"end":475},"obj":"[\"17389686\"]"},{"id":"26578865-195-203-323925","span":{"begin":673,"end":677},"obj":"[\"23212845\"]"}],"attributes":[{"subj":"26578865-128-136-323924","pred":"source","obj":"TEST0"},{"subj":"26578865-195-203-323925","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"26578865-17389686-323924","span":{"begin":471,"end":475},"obj":"17389686"},{"id":"26578865-23212845-323925","span":{"begin":673,"end":677},"obj":"23212845"}],"attributes":[{"subj":"26578865-17389686-323924","pred":"source","obj":"0_colil"},{"subj":"26578865-23212845-323925","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"26578865-17389686-38257405","span":{"begin":471,"end":475},"obj":"17389686"},{"id":"26578865-23212845-38257406","span":{"begin":673,"end":677},"obj":"23212845"}],"attributes":[{"subj":"26578865-17389686-38257405","pred":"source","obj":"2_test"},{"subj":"26578865-23212845-38257406","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ec93b4","default":true},{"id":"0_colil","color":"#93ceec"},{"id":"2_test","color":"#e8ec93"}]}]}}