PMC:4589673 / 6196-7204 JSONTXT

{"project":"TEST0","denotations":[{"id":"26483626-130-138-394561","span":{"begin":130,"end":134},"obj":"[\"17764852\"]"},{"id":"26483626-149-157-394562","span":{"begin":149,"end":153},"obj":"[\"20108223\"]"},{"id":"26483626-171-179-394563","span":{"begin":171,"end":175},"obj":"[\"22844515\"]"},{"id":"26483626-192-200-394564","span":{"begin":192,"end":196},"obj":"[\"25538559\"]"},{"id":"26483626-210-218-394565","span":{"begin":210,"end":214},"obj":"[\"24454279\"]"}],"text":"Previous studies have revealed dynamic regulation of mRNA and microRNA expression in long-term synaptic plasticity (Håvik et al., 2007; Ryan et al., 2011; Wibrand et al., 2012; Joilin et al., 2014; Pai et al., 2014). Here, we report the first global transcriptome analysis of in vivo synaptic plasticity, using the well-established model of LTP in the rat dentate gyrus (DG). The dentate gyrus (DG), a subregion of the hippocampus, is involved in processing information that results in declarative memory formation. Using RNA-seq we have identified a number of novel lncRNAs that are dynamically regulated in response to LTP. In addition, we also observed an altered expression of multiple classes of repeat elements including retrotransposons. Taken together, the identification of dynamic expression of these groups of noncoding RNAs in response to synaptic activation opens new avenues for future studies into the mechanisms surrounding synaptic plasticity, memory formation, and human cognitive diseases."}

{"project":"0_colil","denotations":[{"id":"26483626-17764852-394561","span":{"begin":130,"end":134},"obj":"17764852"},{"id":"26483626-20108223-394562","span":{"begin":149,"end":153},"obj":"20108223"},{"id":"26483626-22844515-394563","span":{"begin":171,"end":175},"obj":"22844515"},{"id":"26483626-25538559-394564","span":{"begin":192,"end":196},"obj":"25538559"},{"id":"26483626-24454279-394565","span":{"begin":210,"end":214},"obj":"24454279"}],"text":"Previous studies have revealed dynamic regulation of mRNA and microRNA expression in long-term synaptic plasticity (Håvik et al., 2007; Ryan et al., 2011; Wibrand et al., 2012; Joilin et al., 2014; Pai et al., 2014). Here, we report the first global transcriptome analysis of in vivo synaptic plasticity, using the well-established model of LTP in the rat dentate gyrus (DG). The dentate gyrus (DG), a subregion of the hippocampus, is involved in processing information that results in declarative memory formation. Using RNA-seq we have identified a number of novel lncRNAs that are dynamically regulated in response to LTP. In addition, we also observed an altered expression of multiple classes of repeat elements including retrotransposons. Taken together, the identification of dynamic expression of these groups of noncoding RNAs in response to synaptic activation opens new avenues for future studies into the mechanisms surrounding synaptic plasticity, memory formation, and human cognitive diseases."}

{"project":"2_test","denotations":[{"id":"26483626-17764852-38317118","span":{"begin":130,"end":134},"obj":"17764852"},{"id":"26483626-20108223-38317119","span":{"begin":149,"end":153},"obj":"20108223"},{"id":"26483626-22844515-38317120","span":{"begin":171,"end":175},"obj":"22844515"},{"id":"26483626-25538559-38317121","span":{"begin":192,"end":196},"obj":"25538559"},{"id":"26483626-24454279-38317122","span":{"begin":210,"end":214},"obj":"24454279"}],"text":"Previous studies have revealed dynamic regulation of mRNA and microRNA expression in long-term synaptic plasticity (Håvik et al., 2007; Ryan et al., 2011; Wibrand et al., 2012; Joilin et al., 2014; Pai et al., 2014). Here, we report the first global transcriptome analysis of in vivo synaptic plasticity, using the well-established model of LTP in the rat dentate gyrus (DG). The dentate gyrus (DG), a subregion of the hippocampus, is involved in processing information that results in declarative memory formation. Using RNA-seq we have identified a number of novel lncRNAs that are dynamically regulated in response to LTP. In addition, we also observed an altered expression of multiple classes of repeat elements including retrotransposons. Taken together, the identification of dynamic expression of these groups of noncoding RNAs in response to synaptic activation opens new avenues for future studies into the mechanisms surrounding synaptic plasticity, memory formation, and human cognitive diseases."}