PMC:4572492 / 3598-4324 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4572492","sourcedb":"PMC","sourceid":"4572492","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4572492","text":"Lung disease in CF is distinct, being progressive and notably affected by environmental exposures such as infection history, secondhand smoke, air pollution, and ambient air temperature,9–11 with a ∼50% estimated heritability.12 Similar to the intestinal epithelia, the apical membrane constituents of lung epithelia should likewise contribute to disease. Testing this, or any hypothesis in CF lung disease, however, has the added difficulty of being able to specify and collect accurate information on the contributing exposure variables and model the potential GxE. Therefore, an alternative association testing methodology is needed to account for the effects of interacting variables that are either unknown or unmeasured.","tracks":[{"project":"2_test","denotations":[{"id":"26140448-18230779-2053681","span":{"begin":188,"end":190},"obj":"18230779"},{"id":"26140448-14718248-2053681","span":{"begin":188,"end":190},"obj":"14718248"},{"id":"26140448-22125624-2053681","span":{"begin":188,"end":190},"obj":"22125624"},{"id":"26140448-17332481-2053682","span":{"begin":226,"end":228},"obj":"17332481"}],"attributes":[{"subj":"26140448-18230779-2053681","pred":"source","obj":"2_test"},{"subj":"26140448-14718248-2053681","pred":"source","obj":"2_test"},{"subj":"26140448-22125624-2053681","pred":"source","obj":"2_test"},{"subj":"26140448-17332481-2053682","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#e193ec","default":true}]}]}}