PMC:4570283 / 11070-12695 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4570283","sourcedb":"PMC","sourceid":"4570283","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4570283","text":"The Kalash Are a Genetic Isolate\nPCA using only Eurasian and South Asian populations separated the populations from Europe, Caucasus, and West Asia from East Asians in the first component and from South and Central Asians in the second component; Central Asians lay closer to the Sherpa from Nepal and CHB from East Asia. The Kalash samples clustered together as an outlier population to the other South Asian samples from India and Pakistan (Figure 1B). The Kalash genetic isolation was also supported by the ADMIXTURE plot (Figure 1C), in which the lowest cross-validation error was achieved with seven ancestry components. In this analysis, the Kalash were characterized mainly by a unique genetic component (dark green), although many samples shared a proportion of their ancestry with their neighbors in Pakistan (light orange and light blue). This light-blue component was also shared among many diverse populations from West, Central, and South Asia.\nThe pattern of runs of homozygosity (Figures S1A and S1B) and LD decay (Figure S2) reveal the highest average level of homozygosity in the Kalash and most extensive LD, possibly reflecting a high level of isolation and low effective population size. The f3 test statistic (Table S3), ALDER (Table S4), and TreeMix analysis (Figure S3) also test for admixture, but they showed no evidence of gene flow into the Kalash and thus provide further support for their genetic isolation. The TreeMix5 analysis supports most strongly an un-rooted tree that has 11 migration edges and shows extreme genetic drift in the Kalash but no migration events affecting them (Figure S3).","divisions":[{"label":"title","span":{"begin":0,"end":32}},{"label":"p","span":{"begin":33,"end":957}}],"tracks":[{"project":"2_test","denotations":[{"id":"25937445-18292342-2051095","span":{"begin":1448,"end":1449},"obj":"18292342"}],"attributes":[{"subj":"25937445-18292342-2051095","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93e8","default":true}]}]}}