PMC:4561322 / 7558-8902 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4561322","sourcedb":"PMC","sourceid":"4561322","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4561322","text":"Tanshinone IIA, cryptotanshinone, salvianolic acid A, salvianolic acid B, tanshinol, and protocatechuic aldehyde are from Salvia miltiorrhiza which is a classical traditional Chinese medicine (TCM) which can promote blood circulation and remove blood stasis with 1000 years of clinical application [27]. It has been demonstrated that Salvia miltiorrhiza can reduce the area of cerebral infarct of ischemia-reperfusion injury rats which results from blood stasis [28]. The chemical components of Salvia miltiorrhiza are divided into water-soluble and liposoluble components. Among the liposoluble components, tanshinone IIA [29] has been reported to improve blood stasis syndrome of patients with coronary heart diseases by inhibiting the circulating inflammatory markers (including IL-6, TNF α, VCAM-1, CD40, sCD40L, MCP-1, and MMP9). Cryptotanshinone [30] has good pharmacological effects on atherosclerosis, while atherosclerosis is one of the diseases resulting from blood stasis. Salvianolic acids, as the main effective components of water-soluble components including salvianolic acid A, salvianolic acid B, tanshinol, and protocatechuic aldehyde, can inhibit thrombosis, thromboxane B2 formation, and platelet aggregation [31]. This indicated that the main active components from Salvia miltiorrhiza are all associated with blood stasis.","tracks":[]}