PMC:4548004 / 9779-12646 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/4548004","sourcedb":"PMC","sourceid":"4548004","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4548004","text":"Metabolic parameters were measured to confirm whether human apoB Tg. SHR-cp/cp rats met the criterion for metabolic syndrome. Thirty-six-week-old male human apoB Tg. SHR-cp/cp rats showed higher body weight levels when fed the western diet than human apoB Tg. SHR-+/+ and non-Tg. SHR-+/+ rats (Table 1\nTable 1. Metabolic parameters in human apoB Tg. SHR-cp/cp rats\nApoB Tg. cp/cp Non-Tg. cp/cp ApoB Tg. +/+ Non-Tg. +/+\nn 9 8 7 7\nBody weight (g) 911 ± 20.8 963 ± 8.6 520 ± 15.5** 541 ± 11.9**\nPlasma insulin (ng/ml) 35 ± 5.9 23 ± 1.6 3 ± 0.2** 3 ± 0.3**\nPlasma glucose (mg/dl) 202 ± 33.8 203 ± 26.9 129 ± 2.7 145 ± 2.5\nPlasma TC (mg/dl) 1,513 ± 89.1 176 ± 9.2** 465 ± 10.1** 73 ± 1.8**\nPlasma TG (mg/dl) 1,044 ± 61.4 313 ± 149.9** 361 ± 12.8** 82 ± 10.5**\nPlasma human apoB (mg/dl) 1,147 ± 40.2 0 ± 0** 406 ± 11.6** 0 ± 0**\nPlasma HDL-c (mg/dl) 18 ± 2.1 40 ± 2.3** 5 ± 0.3** 24 ± 1.0\nSystolic blood pressure (mmHg) 139 ± 9.0 153 ± 2.0 150 ± 3.0 168 ± 4**\nData are shown as the mean ± SE. **P\u003c0.01 compared with human apoB Tg.-cp/cp rats.). There were no significant differences in body weight between human apoB Tg. SHR-cp/cp rats and non-Tg. SHR-cp/cp rats (Table 1). Twelve-week-old male human apoB Tg. SHR-cp/cp rats showed higher plasma insulin levels when fed the western diet than human apoB Tg. SHR-+/+ and non-Tg. SHR-+/+ rats after overnight fasting, although there were no significant differences in plasma glucose levels between the 4 strains (Table 1). There were no significant differences in plasma insulin levels between human apoB Tg. SHR-cp/cp rats and non-Tg. SHR-cp/cp rats (Table 1). Twelve-week-old human apoB Tg. SHR-cp/cp rats showed plasma total cholesterol (TC) and TG levels of more than 1,000 mg/dl when fed the MF-based western diet beginning at 8 weeks old. Then human apoB Tg. SHR-cp/cp rats showed stable hyperlipidemia during the experimental period (Supplemental Fig. 1). Thirty-six-week-old male human apoB Tg. SHR-cp/cp rats also showed higher total plasma TC, TG, and human apoB levels when fed the western diet than their littermates, human apoB Tg. SHR-+/+, non-Tg. SHR-cp/cp, and non-Tg. SHR-+/+ rats (Table 1). Plasma human apoB protein was detected in only human apoB Tg. rats (Table 1). Thirty-six-week-old male human apoB Tg. SHR-cp/cp rats showed lower plasma HDL-cholesterol levels when fed the western diet than non-Tg. SHR-cp/cp rats (Table 1). Systolic blood pressure (SBP) in each strain was measured by the tail-cuff method in 12-week-old rats, and there were no significant differences among human apoB Tg. SHR-cp/cp, human apoB Tg. SHR-+/+, and non-Tg. SHR-cp/cp rats (Table 1). However, non-Tg. SHR-+/+ rats showed a significantly higher SBP than human apoB Tg. SHR-cp/cp rats. The human apoB transgene had no effect on metabolic parameters, obesity, diabetes, or hypertension, with the exception of hyperlipidemia.","divisions":[{"label":"table-wrap","span":{"begin":302,"end":1036}},{"label":"label","span":{"begin":302,"end":310}},{"label":"caption","span":{"begin":311,"end":364}},{"label":"title","span":{"begin":311,"end":364}},{"label":"table","span":{"begin":365,"end":953}},{"label":"tr","span":{"begin":365,"end":418}},{"label":"th","span":{"begin":365,"end":379}},{"label":"th","span":{"begin":380,"end":393}},{"label":"th","span":{"begin":394,"end":406}},{"label":"th","span":{"begin":407,"end":418}},{"label":"tr","span":{"begin":419,"end":428}},{"label":"td","span":{"begin":419,"end":420}},{"label":"td","span":{"begin":421,"end":422}},{"label":"td","span":{"begin":423,"end":424}},{"label":"td","span":{"begin":425,"end":426}},{"label":"td","span":{"begin":427,"end":428}},{"label":"tr","span":{"begin":429,"end":491}},{"label":"td","span":{"begin":429,"end":444}},{"label":"td","span":{"begin":445,"end":455}},{"label":"td","span":{"begin":456,"end":465}},{"label":"td","span":{"begin":466,"end":478}},{"label":"td","span":{"begin":479,"end":491}},{"label":"tr","span":{"begin":492,"end":552}},{"label":"td","span":{"begin":492,"end":514}},{"label":"td","span":{"begin":515,"end":523}},{"label":"td","span":{"begin":524,"end":532}},{"label":"td","span":{"begin":533,"end":542}},{"label":"td","span":{"begin":543,"end":552}},{"label":"tr","span":{"begin":553,"end":617}},{"label":"td","span":{"begin":553,"end":575}},{"label":"td","span":{"begin":576,"end":586}},{"label":"td","span":{"begin":587,"end":597}},{"label":"td","span":{"begin":598,"end":607}},{"label":"td","span":{"begin":608,"end":617}},{"label":"tr","span":{"begin":618,"end":684}},{"label":"td","span":{"begin":618,"end":635}},{"label":"td","span":{"begin":636,"end":648}},{"label":"td","span":{"begin":649,"end":660}},{"label":"td","span":{"begin":661,"end":673}},{"label":"td","span":{"begin":674,"end":684}},{"label":"tr","span":{"begin":685,"end":754}},{"label":"td","span":{"begin":685,"end":702}},{"label":"td","span":{"begin":703,"end":715}},{"label":"td","span":{"begin":716,"end":729}},{"label":"td","span":{"begin":730,"end":742}},{"label":"td","span":{"begin":743,"end":754}},{"label":"tr","span":{"begin":755,"end":822}},{"label":"td","span":{"begin":755,"end":780}},{"label":"td","span":{"begin":781,"end":793}},{"label":"td","span":{"begin":794,"end":801}},{"label":"td","span":{"begin":802,"end":814}},{"label":"td","span":{"begin":815,"end":822}},{"label":"tr","span":{"begin":823,"end":882}},{"label":"td","span":{"begin":823,"end":843}},{"label":"td","span":{"begin":844,"end":852}},{"label":"td","span":{"begin":853,"end":863}},{"label":"td","span":{"begin":864,"end":873}},{"label":"td","span":{"begin":874,"end":882}},{"label":"tr","span":{"begin":883,"end":953}},{"label":"td","span":{"begin":883,"end":913}},{"label":"td","span":{"begin":914,"end":923}},{"label":"td","span":{"begin":924,"end":933}},{"label":"td","span":{"begin":934,"end":943}},{"label":"td","span":{"begin":944,"end":953}},{"label":"table-wrap-foot","span":{"begin":954,"end":1036}},{"label":"p","span":{"begin":954,"end":1036}}],"tracks":[]}