PMC:4548004 / 2507-3247 JSONTXT

{"project":"2_test","denotations":[{"id":"25912321-1977530-29848491","span":{"begin":270,"end":272},"obj":"1977530"},{"id":"25912321-8134359-29848492","span":{"begin":394,"end":395},"obj":"8134359"},{"id":"25912321-8254057-29848493","span":{"begin":397,"end":399},"obj":"8254057"},{"id":"25912321-8134359-29848494","span":{"begin":631,"end":632},"obj":"8134359"},{"id":"25912321-8254057-29848495","span":{"begin":634,"end":636},"obj":"8254057"},{"id":"25912321-6254962-29848496","span":{"begin":737,"end":738},"obj":"6254962"}],"text":"To exacerbate dyslipidemia in SHR-cp/cp rats, we generated human apolipoprotein B-100 (apoB-100) transgenic (Tg.) SHR-cp/cp rats. ApoB plays a central role in mammalian lipoprotein metabolism, and apoB-100 is the key structural protein in the formation of lipoproteins [29]. Human apoB-100 Tg. mice show increased plasma total cholesterol and triglyceride levels as compared with non-Tg. mice [2, 11]. It could be expected that a transgene of human apoB in rats would provoke hyperlipidemia due to increased production of human apoB in the liver and/or reduced catabolism of human apoB-containing lipoproteins, as well as in mice [2, 11]. In fact, human LDL binds poorly to rat cell receptors on rat fibroblasts and smooth muscle cells [7]."}

{"project":"MyTest","denotations":[{"id":"25912321-1977530-29848491","span":{"begin":270,"end":272},"obj":"1977530"},{"id":"25912321-8134359-29848492","span":{"begin":394,"end":395},"obj":"8134359"},{"id":"25912321-8254057-29848493","span":{"begin":397,"end":399},"obj":"8254057"},{"id":"25912321-8134359-29848494","span":{"begin":631,"end":632},"obj":"8134359"},{"id":"25912321-8254057-29848495","span":{"begin":634,"end":636},"obj":"8254057"},{"id":"25912321-6254962-29848496","span":{"begin":737,"end":738},"obj":"6254962"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"To exacerbate dyslipidemia in SHR-cp/cp rats, we generated human apolipoprotein B-100 (apoB-100) transgenic (Tg.) SHR-cp/cp rats. ApoB plays a central role in mammalian lipoprotein metabolism, and apoB-100 is the key structural protein in the formation of lipoproteins [29]. Human apoB-100 Tg. mice show increased plasma total cholesterol and triglyceride levels as compared with non-Tg. mice [2, 11]. It could be expected that a transgene of human apoB in rats would provoke hyperlipidemia due to increased production of human apoB in the liver and/or reduced catabolism of human apoB-containing lipoproteins, as well as in mice [2, 11]. In fact, human LDL binds poorly to rat cell receptors on rat fibroblasts and smooth muscle cells [7]."}